Fig. 3

Sex-specific associations between age and HbA1c levels in the SHIP-0 and SHIP-Trend population. a) Linear regression analysis with restricted cubic splines (in case of significant likelihood ratio test, see method section) and b) estimated mean levels with 95% confidence interval assessed by analysis of variance (ANOVA). All models were adjusted for body mass index. The definition of healthy subjects is given in Fig. 1 and the regression estimates in Table 2