Fig. 1

Distribution schematic of the transmembrane topology of the 9 identified variants of ABCC8 gene. The transmembrane domains (TMD) include TMD0, TMD1, and TMD2. The nucleotide-binding domains (NBD) are indicated by NBD1 and NBD2, and the cytosolic loops 3 is between TMD0 and TMD1, respectively. The red bar refers to the ATP binding sites