Association of neutrophil-lymphocyte ratio with all-cause and cardiovascular mortality in US adults with diabetes and prediabetes: a prospective cohort study

Table 2a Hazard ratios for all-cause and CVD mortality by tertiles of NLR levels in subjects with diabetes

NLR	Per 1 unit increment	Tertiles of NLR levels			P for trend
NLR	Per 1 unit increment	Tertile 1	Tertile 2	Tertile 3	P for trend
All-cause mortality
No. deaths/total	1909/7246	494/2415	587/2406	828/2425
Not adjusted	1.30(1.23, 1.37)	1.00(ref)	1.21(1.05, 1.40)	1.82(1.58, 2.09)	<0.0001
Model1	1.22(1.16, 1.28)	1.00(ref)	1.09(0.94, 1.27)	1.52(1.31, 1.77)	<0.0001
Model2	1.22(1.16, 1.28)	1.00(ref)	1.11(0.95, 1.29)	1.53(1.32, 1.78)	<0.0001
Model3	1.16(1.10, 1.23)	1.00(ref)	1.06(0.91, 1.23)	1.37(1.19, 1.58)	<0.0001
CVD mortality
No. deaths/total	671/6008	163/2006	206/2003	302/1999
Not adjusted	1.36(1.24, 1.50)	1.00(ref)	1.28(1.02, 1.61)	1.93(1.52, 2.45)	<0.0001
Model1	1.29(1.18, 1.41)	1.00(ref)	1.14(0.89, 1.45)	1.65(1.32, 2.08)	<0.0001
Model2	1.30(1.20, 1.42)	1.00(ref)	1.16(0.91, 1.48)	1.67(1.33, 2.10)	<0.0001
Model3	1.25(1.14, 1.37)	1.00(ref)	1.16(0.91, 1.48)	1.63(1.29, 2.05)	<0.0001

Model 1: Adjusted for age (< 65 or > = 65years), sex (male or female), race/ethnicity (Hispanic Mexican, non-Hispanic black, non-Hispanic white, or others), marital status (married/Cohabitating, not married), family income-to-poverty ratio (< 1.0, 1.0–3.0, or ≥ 3.0), education level (less than high school, high school or equivalent, or college or above);
Model 2: model 1 adjustments + BMI (< 30 or ≥ 30.0 kg/m2), smoking status (never, former, or current), drinking status (non-drinker or ever drinker), physical activity (low or high), HEI scores, cancer (no or yes);
Model 3: model 2 adjustments + eGFR (< 30, 30–60, >=60 ml/min/1.73 m²), HbA1c (< 7% or > = 7%), diabetes duration (< 10 or ≥ 10 years), anemia (no or yes), CVD (no or yes), hypertension (no or yes), hyperlipidemia (no or yes), depression (no or yes), COPD (no or yes), use of antidiabetic drug (no or yes), use of hypotensive drug (no or yes), use of lipid-lowering drug (no or yes)

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