Association of neutrophil-lymphocyte ratio with all-cause and cardiovascular mortality in US adults with diabetes and prediabetes: a prospective cohort study

Table 2b Hazard ratios for all-cause and CVD mortality by tertiles of NLR levels in subjects with prediabetes

NLR	Per 1 unit increment	Tertiles of NLR levels			P for trend
NLR	Per 1 unit increment	Tertile 1	Tertile 2	Tertile 3	P for trend
All-cause mortality
No. deaths/total	1974/13,024	460/4397	584/4279	930/4348
Not adjusted	1.40(1.33, 1.48)	1.00(ref)	1.17(0.97, 1.40)	1.83(1.59, 2.10)	<0.0001
Model1	1.20(1.13, 1.28)	1.00(ref)	1.09(0.91, 1.29)	1.37(1.18, 1.59)	<0.0001
Model2	1.18(1.11, 1.25)	1.00(ref)	1.06(0.90, 1.26)	1.33(1.14, 1.54)	<0.0001
Model3	1.12(1.05, 1.19)	1.00(ref)	1.05(0.88, 1.24)	1.21(1.03, 1.43)	0.01
CVD mortality
No. deaths/total	616/11,666	121/3911	177/3868	318/3887
Not adjusted	1.60(1.47, 1.75)	1.00(ref)	1.32(0.96, 1.80)	2.36(1.82, 3.06)	<0.0001
Model1	1.34(1.21, 1.48)	1.00(ref)	1.20(0.87, 1.64)	1.66(1.24, 2.21)	<0.0001
Model2	1.33(1.20, 1.48)	1.00(ref)	1.18(0.86, 1.61)	1.66(1.24, 2.22)	<0.0001
Model3	1.24(1.11, 1.37)	1.00(ref)	1.21(0.88, 1.67)	1.49(1.08, 2.04)	0.01

Model 1: Adjusted for age (< 65 or > = 65years), sex (male or female), race/ethnicity (Hispanic Mexican, non-Hispanic black, non-Hispanic white, or others), marital status (married/Cohabitating, not married), family income-to-poverty ratio (< 1.0, 1.0–3.0, or ≥ 3.0), education level (less than high school, high school or equivalent, or college or above);
Model 2: model 1 adjustments + BMI (< 30 or ≥ 30.0 kg/m2), smoking status (never, former, or current), drinking status (non-drinker or ever drinker), physical activity (low or high), HEI scores, cancer (no or yes);
Model 3: model 2 adjustments + eGFR (< 30, 30–60, >=60 ml/min/1.73 m²), anemia (no or yes), hypertension (no or yes), hyperlipidemia (no or yes), depression (no or yes), COPD (no or yes), use of hypotensive drug (no or yes), use of lipid-lowering drug (no or yes)

ISSN: 1472-6823