Lipids as potential mediators linking body mass index to diabetes: evidence from a mediation analysis based on the NAGALA cohort

Table 5 Mediation analysis for BMI and incident diabetes via lipid parameters in the whole population

Mediator	Total effect	Mediation effect	Direct effect	PM(%)	p-value of PM
TC	0.008 (0.004, 0.012)	-0.000 (-0.001, -0.000)	0.008 (0.004, 0.012)	-	-
TG	0.008 (0.004, 0.012)	0.001 (0.001, 0.002)	0.006 (0.003, 0.011)	16.9	< 0.001
HDL-C	0.008 (0.004, 0.012)	0.002 (0.001, 0.003)	0.005 (0.002, 0.009)	30.3	< 0.001
LDL-C^F	0.008 (0.004, 0.012)	-0.000 (-0.001, 0.000)	0.008 (0.004, 0.012)	-	-
LDL-C^S	0.008 (0.003, 0.013)	-0.001 (-0.001, 0.000)	0.009 (0.003, 0.014)	-	-
Non-HDL-C	0.008 (0.004, 0.012)	-0.000 (-0.001, 0.000)	0.008 (0.004, 0.012)	-	-
RC	0.008 (0.004, 0.012)	0.001 (0.000, 0.002)	0.007 (0.003, 0.011)	10.4	0.022
TC/HDL-C ratio	0.008 (0.004, 0.012)	0.003 (0.002, 0.004)	0.005 (0.001, 0.009)	33.8	< 0.001
TG/HDL-C ratio	0.008 (0.004, 0.012)	0.002 (0.002, 0.003)	0.006 (0.002, 0.010)	26.7	< 0.001
LDL/HDL-C ratio	0.008 (0.004, 0.012)	0.002 (0.001, 0.003)	0.005 (0.001, 0.009)	31.6	< 0.001
Non-HDL/HDL-C ratio	0.008 (0.004, 0.012)	0.003 (0.002, 0.004)	0.005 (0.001, 0.009)	33.9	< 0.001
RC/HDL-C ratio	0.008 (0.004, 0.012)	0.003 (0.002, 0.004)	0.005 (0.001, 0.009)	40	< 0.001
TyG index	0.008 (0.003, 0.013)	0.001 (-0.001, 0.001)	0.007 (0.002, 0.012)	-	-

Abbreviations: PM: proportion mediate; other abbreviations as in Table 1
Adjusting variables: sex, age, height, SBP, Fatty liver, habit of exercise, smoking status, drinking status, ALT, AST, GGT, FPG and HbA1c

ISSN: 1472-6823