Lipids as potential mediators linking body mass index to diabetes: evidence from a mediation analysis based on the NAGALA cohort

Table 6 Area under the ROC curve, Specificity, Sensitivity, PPV, and NPV of BMI and BMI combined lipid parameters to predict incident diabetes

	AUC	95%CI low	95%CI upp	Specificity	Sensitivity	PPV	NPV
BMI	0.7327	0.7069	0.7586	0.7184	0.6273	0.0522	0.9873
TC + BMI	0.7369	0.7111	0.7627	0.7471	0.6086	0.0562	0.9872
TG + BMI*	0.7655	0.7406	0.7904	0.7438	0.6273	0.0605	0.9891
HDL-C + BMI*	0.7631	0.7388	0.7874	0.6977	0.7131	0.0522	0.0551
LDL-C^F+ BMI*	0.7468	0.7271	0.7719	0.7164	0.6702	0.0522	0.9877
LDL-C^S+ BMI*	0.7378	0.7124	0.7632	0.6758	0.6836	0.0496	0.9886
Non-HDL-C + BMI*	0.7503	0.7254	0.7753	0.7192	0.6729	0.0560	0.9889
RC + BMI*	0.7655	0.7409	0.7901	0.7186	0.6997	0.0579	2.3902
TC/HDL-C ratio + BMI*	0.7705	0.7468	0.7943	0.7737	0.6354	0.0649	0.9885
TG/HDL-C ratio + BMI*	0.7666	0.7418	0.7915	0.6740	0.7319	0.0526	0.9903
LDL/HDL-C ratio + BMI*	0.7688	0.7450	0.7925	0.7729	0.6273	0.0640	0.9882
Non-HDL/HDL-C ratio + BMI*	0.7705	0.7486	0.7943	0.7737	0.6354	0.0649	0.9885
RC/HDL-C ratio + BMI*	0.7748	0.7509	0.7987	0.8133	0.6086	0.0746	0.9883

ROC, receiver-operating characteristic curve; AUC, area under the ROC curve; PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval; Other abbreviations as in Table 1; *, DeLong test, P < 0.05 compared with BMI

ISSN: 1472-6823