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Table 4 Comparison between normal puberty (no. = 185) and delayed puberty diabetic patients (no. = 15) regarding biochemical data

From: Insulin-like growth factor 1 and sex hormones for assessment of anthropometric and pubertal growth of Egyptian children and adolescents with type 1 diabetes mellitus (single center study)

 

Normal puberty

Delayed puberty

Test value

P -value

No. = 185

No. = 15

CBC

Hb(g/dl)

Mean ± SD

12.12 ± 0.96

11.00 ± 0.76

4.401a

0.000

Range

9.8 – 14.1

9.8 – 13.1

MCV (fl)

Mean ± SD

81.86 ± 3.43

79.87 ± 2.61

2.197a

0.029

Range

71 – 91

76 – 85

PLT (109/L)

Mean ± SD

267.16 ± 49.70

271.80 ± 44.67

-0.350a

0.726

Range

151 – 515

215 – 345

WBC (109/L)

Mean ± SD

5.99 ± 1.06

6.43 ± 1.07

-1.524a

0.129

Range

3.2 – 9.7

4.9 – 8.2

HbA1C%

Mean ± SD

8.04 ± 1.23

9.50 ± 0.66

-4.530a

0.000

Range

5.9 – 14

8.6 – 10.5

CRP (mg/dl)

Median (IQR)

6 (2.8 – 6.4)

1.85 (1.5 – 6)

-2.628b

0.009

Range

1.3 – 26

0.3 – 12

ESR (mm/hr)

Median (IQR)

12 (10 – 14)

12 (9 – 15)

-0.243b

0.808

Range

8 – 22

8 – 22

Creatinine (mg/dl)

Mean ± SD

0.77 ± 0.11

0.83 ± 0.16

-1.910a

0.058

Range

0.1 – 1.1

0.45 – 1.1

ALT (IU/L)

Median (IQR)

11 (9 – 13)

12 (10 – 14)

-1.128b

0.259

Range

6 – 77

9 – 22

AST (IU/L)

Median (IQR)

17 (16 – 19)

17 (15 – 19)

-0.440b

0.660

Range

11 – 70

12 – 23

Lipid profile

Fasting cholesterol(mg/dl)

Mean ± SD

146.48 ± 49.79

175.33 ± 77.82

-2.056a

0.041

Range

85 – 318

76 – 287

HDL (mg/dl)

Mean ± SD

32.90 ± 14.98

44.13 ± 23.53

-2.658a

0.009

Range

9 – 98

19 – 80

LDL (mg/dl)

Mean ± SD

66.91 ± 37.34

96.40 ± 38.60

-2.935a

0.004

Range

29 – 188

57 – 175

TG (mg/dl)

Mean ± SD

91.12 ± 45.27

119.80 ± 52.29

-2.332a

0.021

Range

33 – 312

54 – 199

Urinary albumin/creatinine ratio

Median (IQR)

3 (1.6 – 10)

28 (11 – 49)

-3.791b

0.000

Range

0.3 – 133

0.6 – 70

  1. HDL high density lipoprotein, LDL Low density lipid lipoprotein, TG triglycerides, TTG tissue transglutaminase, FT4 free thyroxine. TSH thyroid stimulating hormone, ESR erythrocytes sedimentation rate, CRP C-reactive protein
  2. P-value > 0.05: Non significant
  3. P-value < 0.05: Significant
  4. P-value < 0.01: Highly significant
  5. aIndependent t-test
  6. bMann-Whitney test