Role of secreted frizzled-related protein 4 in prediabetes and type 2 diabetes: a cross sectional study

BMC Endocrine Disorders

Table 2 Association analysis of rs4720265 with metabolic alterations in T2D subjects

SNP/Gen	Genotype	WC	Glucose mg/dL	Cholesterol mg/dL	Triglycerides mg/dL	HDL-C mg/dL	LDL-C mg/dL	Insulin µU/mL	HOMA-IR	HOMA-β
SFRP4 rs4720265	GG	99 ± 12	129 (102, 180)	192 ± 41	160 (117, 215)	46 (42, 57)	116 ± 34	9.1 (5.9, 14.2)	3.3 (1.7, 4.9)	40 (20, 80)
SFRP4 rs4720265	GA/AA	99 ± 12	137 (113, 180)	190 ± 39	169 (130, 243)	46 (39, 55)	112 ± 36	9.1 (5.9, 13.6)	3.3 (2.0, 5.9)	39 (26, 73)
P		0.192	0.417	0.569	0.076	0.040	0.223	0.676	0.711	0.880

Abbreviations: WC, waist circumference; HDL-C, High density lipoprotein; LDL-C, Low density lipoprotein; HOMA-IR, Homeostatic Model Assessment for Insulin Resistance; HOMA-b, Homeostatic Model Assessment of beta cell function. In bold the mutant genotype is represented. Under the dominant model of inheritance, ANCOVA, in bold P < 0.05; fixed variables BMI, age and sex.

ISSN: 1472-6823