Table 1 General characteristics of patients with Cushing’s syndrome

Age (years)

48.45 ± 14.14

55.84 ± 12.07

50.08 ± 14.00

0.019

Male, %

25 (25.0%)

3 (10.3%)

28 (21.7%)

0.092

BMI, kg/m²

25.11 ± 4.07

25.58 ± 3.12

25.20 ± 3.88

0.61

Sodium, mmol/L

143.77 ± 3.57

142.58 ± 2.35

143.50 ± 3.36

0.096

Potassium, mmol/L

3.59 ± 0.72

3.95 ± 0.51

3.67 ± 0.69

0.012

Cortisol 0800 (nmol/L)

668.17 ± 335.29

399.06 ± 135.10

606.72 ± 321.65

< 0.001

Cortisol 1600 (nmol/L)

594.13 ± 314.92

309.80 ± 173.36

527.63 ± 311.83

< 0.001

Cortisol 2400 (nmol/L)

510.55 ± 269.71

218.80 ± 107.88

442.32 ± 271.32

< 0.001

Cortisol after LDDST (nmol/L)

509.25 ± 276.75

252.16 ± 157.07

447.36 ± 275.57

< 0.001

T3 (nmol/L)

1.20 ± 0.31

1.55 ± 0.73

1.27 ± 0.46

< 0.001

T4 (nmol/L)

79.10 ± 22.80

87.53 ± 20.94

80.90 ± 22.59

0.121

FT3 (pmol/L)

3.27 ± 0.88

3.93 ± 0.78

3.42 ± 0.90

< 0.001

FT4 (pmol/L)

13.95 ± 3.37

15.57 ± 3.25

14.32 ± 3.40

0.024

TSH (µIU/mL)

1.15 ± 0.99

2.25 ± 1.76

1.40 ± 1.29

< 0.001

Thyroid status

0.005

Euthyroid

42 (42.0%)

19 (65.5%)

61 (47.3%)

Pituitary hypothyroidism

33 (33.0%)

1 (3.4%)

34 (26.4%)

Low-T3

22 (22.0%)

6 (20.7%)

28 (21.7%)

Subclinical hypothyroidism

3 (3.0%)

3 (10.3%)

6 (4.7%)

ACTH-dependent

39 (39.0%)

1 (3.4%)

40 (31.0%)

< 0.001

Location

< 0.001

Adrenal

61 (61.0%)

28 (96.6%)

89 (69.0%)

Adenoma

57 (93.4%)

28 (100.0%)

85 (95.5%)

Carcinoma

4 (6.6%)

0 (0.0%)

4 (4.5%)

Size, cm

2.93 ± 1.97

2.71 ± 0.87

2.86 ± 1.70

Surgery

53 (86.9%)

21 (75.0%)

74 (83.1%)

Pituitary

32 (32.0%)

0 (0.0%)

32 (24.8%)

Size, mm

0.42 ± 0.40

0

Surgery

18 (56.2%)

0

Ectopic

7 (7.0%)

1 (3.4%)

8 (6.2%)