Identification of novel risk factors for postoperative severe hypocalcemia in patients with primary hyperparathyroidism undergoing parathyroidectomy: a case control study

Table 4 Binary logistic regression analysis for the development of SH after PTX

Variable	Univariate			Multivariate
Variable	OR	95% CI	P value	OR	95% CI	P value
iPTH (pg/mL)	1.001	0.999 ~ 1.002	0.062
Serum P (μmol/L)	0.989	0.982 ~ 0.997	0.006*	0.989	0.981 ~ 0.996	0.003*
Serum Ca (mmol/L)	0.069	0.005 ~ 0.880	0.04*	0.007	0.001 ~ 0.415	0.017*
Serum Ca/P	2.241	1.127 ~ 4.455	0.021*	0.135	0.019 ~ 0.947	0.044*
Percentage decrease of serum Ca (%)	1.091	1.002 ~ 1.189	0.045*	1.055	0.944 ~ 1.179	0.343
tP1NP (ng/mL)	1.005	1.001 ~ 1.008	0.013*	1.004	0.999 ~ 1.009	0.066
OC (ng/mL)	1.012	1.003 ~ 1.021	0.01*	1.012	1.001 ~ 1.024	0.036*
ALP (U/L)	1.004	1.001 ~ 1.007	0.019*	1.003	0.999 ~ 1.007	0.12

^* P < 0.05. OR Odds ratio, 95% CI 95% confidence interval, SH Severe hypocalcemia, PTX Parathyroidectomy, iPTH intact parathyroid hormone, serum P serum phosphorus, serum Ca preoperative serum calcium, serum Ca/P preoperative serum calcium/serum phosphorus, tP1NP total procollagen type 1 intact N-terminal propeptide, OC Osteocalcin, ALP Alkaline phosphatase

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