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Table 4 Sparing confirmatory testing rate

From: Sparing confirmatory testing in primary aldosteronism (SCIPA): a multicenter retrospective diagnostic accuracy study

3 combinations

Sparing confirmatory testing rate

A1:

PAC > 10 ng/dL + PRA < 1.0 ng/dL/hr + spont. hypoK

48.8% (41/84)

A2:

PAC > 15 ng/dL + PRA < 1.0 ng/dL/hr + spont. hypoK

44.0% (37/84)

A3:

PAC > 20 ng/dL + PRA < 1.0 ng/dL/hr + spont. hypoK

34.5% (29/84)

A4:

PAC > 25 ng/dL + PRA < 1.0 ng/dL/hr + spont. hypoK

27.4% (23/84)

A5:

PAC > 10 ng/dL + PRA < 0.6 ng/dL/hr + spont. hypoK

46.4% (39/84)

A6:

PAC > 15 ng/dL + PRA < 0.6 ng/dL/hr + spont. hypoK

41.7% (35/84)

A7:

PAC > 20 ng/dL + PRA < 0.6 ng/dL/hr + spont. hypoK

34.5% (29/84)

A8:

PAC > 25 ng/dL + PRA < 0.6 ng/dL/hr + spont. hypoK

27.4% (23/84)

2 combinations

B1:

PAC > 10 ng/dL + PRA < 1.0 ng/dL/hr

79.8% (67/84)

B2:

PAC > 15 ng/dL + PRA < 1.0 ng/dL/hr

66.7% (56/84)

B3:

PAC > 20 ng/dL + PRA < 1.0 ng/dL/hr

48.8% (41/84)

B4:

PAC > 25 ng/dL + PRA < 1.0 ng/dL/hr

41.7% (35/84)

B5:

PAC > 10 ng/dL + PRA < 0.6 ng/dL/hr

67.9% (57/84)

B6:

PAC > 15 ng/dL + PRA < 0.6 ng/dL/hr

54.8% (46/84)

B7:

PAC > 20 ng/dL + PRA < 0.6 ng/dL/hr

41.7% (35/84)

B8:

PAC > 25 ng/dL + PRA < 0.6 ng/dL/hr

32.1% (27/84)

  1. Legend: PAC plasma aldosterone concentration, PRA plasma renin activity, Spont. hypoK – spontaneous hypokalemia
  2. *The sparing confirmatory testing rate was defined as the number of patients who can skip the confirmatory test for PA based on each criterion divided by the number of patients who were diagnosed as PA based on SIT confirmatory test.