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Table 3 Literature review

From: Rare correlation of somatic PRKACA mutations with pregnancy-associated aldosterone- and cortisol-producing adenomas: a case report and literature review

year

pmid

Case

gender

age

hypertension

hypopotassemia

pathologic changes in the adrenal glands

Tumor volume

specific immunohistochemistry

Mutation Gene

Obvious CS

2022

35,960,046

1

female

53

yes

yes

right adrenocortical adenoma

3 cm × 2.3 cm × 1.7 cm

CYP11B1(+), CYP11B2(+), CaSR(+), VD3R(+), PTH1R (+)

-

no

2022

35,960,046

2

male

59

yes

no

right adrenocortical adenoma

2.5 cm × 2.2 cm × 2 cm

CYP11B1(+), CYP11B2(+), CaSR(+), VD3R(+), PTH1R (+)

-

no

2022

35,707,125

1

female

49

yes

yes

right adrenocortical adenoma, light yellow

2 cm × 1.7 cm × 1 cm

-

-

no

2022

35,399,924

1

female

46

yes

yes

bilateral adrenal glands multiple aldosterone-producing micronodules(mAPM), aldosterone adenoma

1.6 cm(right), 2.1 cm(left)

CYP11B2(right, +), CYP11B1(left, +)

KCNJ5 (right side); PRKACA (left side)

no

2021

34,657,370

1

male

34

yes

yes

right adrenocortical adenoma

6.3 cm × 6 cm

CYP11B2(+), CYP11B1(-)

-

no

2021

34,384,396

1

female

67

yes

no

right Adrenal gland tumor

2.5 cm × 2.2 cm

CYP11B1(+), CYP11B2(-)

-

yes

2020

33,434,176

1

female

56

yes

yes

left adrenal gland tumor, golden-orange

4.5 cm × 3.1 cm × 3.2 cm

-

-

no

2016

8,533,534

1

female

50

yes

yes

right adrenal gland tumor, 2/3 golden yellow, 1/3 sepia

30 mm

-

-

yes

2014

25,228,847

1

female

29

yes

yes

left adrenocortical adenoma, golden yellow

2.1 cm × 1.6 cm

HSD3β1(+), P450-17A1(+)

-

no

2011

22,071,263

1

female

70

yes

yes

left adrenocortical adenoma, yellow

2 cm

 

-

no

2011

21,297,325

1

male

52

yes

yes

bilateral adrenal tumor

4.0 cm × 2.5 cm ×2.6 cm(left), 1 cm × 2.5 cm × 2 cm(right)

3β-HSD(+), P450C17(+)

-

no

2010

20,186,151

1

female

57

yes

yes

left adrenocortical adenoma

2.9 cm × 3.1 cm

CYP17(+)

-

yes

2010

20,186,151

2

female

49

yes

yes

right adrenocortical adenoma

3.5 cm

CYP17(+)

-

yes

2010

20,463,748

1

female

54

yes

no

right adrenal tumor, bilateral microAPA

2.5 cm(right), 2.1 mm(right), 1.6 mm(left), 1.9 mm(left)

3β-HSD(+), P450C17(+)

-

yes

2008

18,772,856

1

male

62

yes

yes

right adrenocortical adenoma, golden yellow

4.5 cm × 4.5 cm × 4.0 cm

-

-

no

2008

18,543,063

1

male

50

yes

yes

bilateral adrenocortical adenoma, golden yellow

1 cm × 1 cm(left), 1.1 cm × 0.8 cm (+)

3β-HSD(+), P450C17(+)

-

no

2007

17,541,216

1

female

35

yes

yes

left adrenocortical adenoma, golden-yellow

3 cm

P450c17(+)

-

no

2007

17,379,961

1

female

57

yes

no

right adrenal tumors, golden yellow with a few brown areas

2.1 cm, 1.9 cm

SCC(+), 3β-HSD II(+), CYP 21(+), CYP 11 B1(+), CYP 17(+)

-

no

2005

16,613,821

1

female

39

yes

no

left adrenocortical adenoma

3.0 cm X 2.5 cm

-

-

no

2002

12,487,169

1

female

43

yes

yes

right adrenocortical adenoma, golden yellow

4 cm

3β-HSD(+), P450 (aldo)(+), P450(11beta) (+)

-

yes

2023

-

1

female

29

yes

yes

right adrenocortical adenoma, grayish yellow-brown

2.9 cm × 2.4 cm

CYP11B1(+), CYP11B2(+), LHCGR(+)

PRKACA

yes

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BMC Endocrine Disorders

ISSN: 1472-6823

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