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Table 3 Laboratory investigations at admission of the initially diagnosed T1DM and T2DM patients presenting with DKA

From: Comparison of clinical characteristics and treatment outcomes between initially diagnosed type 1 and type 2 diabetes mellitus patients presenting with diabetic ketoacidosis

 

All Diabetes

(N = 155)

T1DM

(N = 15)

T2DM

(N = 85)

p value*

Plasma glucose (mmol/L)

39.6 + 18.5

31.7 ± 12.2

42.9 ± 22.1

0.001

HbA1c (%)

13.2 + 3.3

12.7 ± 4.7

13.6 ± 3

0.483

eGFR (ml/min/1.73m2)

75.9 + 39.9

105.2 ± 37.1

71.9 ± 39.9

0.025

Sodium (mmol/L)

129 + 9.4

131 ± 10.5

130 ± 10.4

0.665

Potassium (mmol/L)

4.7 + 1

4.6 ± 1

4.8 ± 1.1

0.536

Chloride (mmol/L)

89 + 9.8

93 ± 9.2

90 ± 10.7

0.286

Bicarbonate (mmol/L)

10 + 5.3

10 ± 4.7

10 ± 4.9

0.876

pH in arterial/venous blood gas

7.23 + 0.16

7.21 ± 0.14

7.25 ± 0.14

0.323

Ketone (mmol/L)

5.1 + 2.3

5.5 ± 2.2

5.3 ± 2.3

0.872

Effective serum osmolality (mOsmol/kg)

296 + 24.1

293 ± 23.1

300 ± 26.8

0.331

Positive Anti-GADa

13 (23.6)

13 (92.9)

0

< 0.001

Anti-GAD level (U/mL)b

0.07

(0.01–1596.9)

8.17

(3.63–24.66)

0.02

(0.01–0.11)

< 0.001

Positive Anti-IA2a

3 (16.7)

3 (42.9)

0

0.063

  1. Notes: Data are reported as mean ± standard deviation or number (percentage), as appropriate. * p-value when T1DM was compared with T2DM. aTotal population who was tested for pancreatic autoantibodies, N = 55. bData are reported as median (25th -75th percentile)
  2. Abbreviations: Anti-GAD: Anti-glutamic acid decarboxylase 65; Anti-IA2: Anti-islet antigen 2; DKA: diabetic ketoacidosis; eGFR: estimated glomerular filtration rate; HbA1c: glycated hemoglobin; T1DM: type 1 diabetes mellitus; T2DM: type 2 diabetes mellitus