Table 1 Baseline characteristics of participants in the NHANES 2007–2012, weighted
Serum α-klotho (pg/mL) | P value | |||||
|---|---|---|---|---|---|---|
All | Q1(< 661.6) | Q2(661.6-806.6) | Q3(806.6–982.0) | Q4(> 982.0) | ||
N(unweighted) | (n = 4614) | (n = 1194) | (n-1114) | (n = 1092) | (n = 1214) | |
Age | 54.00(47.00, 63.00) | 55.00(47.00, 65.00) | 54.00(47.00, 63.00) | 53.00(47.00, 63.00) | 53.00(46.00, 61.00) | 0.008 |
Gender (%) | 0.014 | |||||
Male | 48.4 | 50.5 | 52.3 | 47.7 | 42.9 | |
Female | 51.6 | 49.5 | 47.7 | 52.3 | 57.1 | |
Race (%) | 0.003 | |||||
Mexican American | 6.0 | 5.8 | 5.7 | 5.8 | 6.5 | |
Other Hispanic | 4.5 | 4.0 | 5.0 | 4.2 | 4.8 | |
Non-Hispanic White | 74.5 | 75.9 | 77.2 | 74.8 | 70.2 | |
Non-Hispanic Black | 9.3 | 9.5 | 7.6 | 7.8 | 12.3 | |
Other race | 5.7 | 4.8 | 4.6 | 7.4 | 6.2 | |
Marital status (%) | 0.461 | |||||
Married or living with partner | 70.5 | 70.1 | 71.4 | 72.4 | 68.0 | |
Unmarried or living alone | 29.5 | 29.9 | 28.6 | 27.6 | 32.0 | |
Education (%) | 0.793 | |||||
< High school diploma | 19.0 | 18.7 | 20.2 | 18.1 | 19.1 | |
High school diploma | 23.9 | 24.4 | 21.8 | 24.8 | 24.5 | |
> High school diploma | 57.1 | 56.9 | 58.0 | 57.1 | 56.4 | |
Household income, $(%) | 0.915 | |||||
< 20,000 | 14.6 | 14.8 | 14.1 | 15.0 | 14.7 | |
≥ 20,000 | 85.4 | 85.2 | 85.9 | 85.0 | 85.3 | |
Smoking status (%) | 0.554 | |||||
Never | 50.0 | 47.6 | 49.1 | 49.3 | 53.9 | |
Former | 20.0 | 20.8 | 20.3 | 20.1 | 18.7 | |
Current | 30.0 | 31.5 | 30.6 | 30.6 | 27.3 | |
Diabetes (%) | 0.466 | |||||
Yes | 13.2 | 12.4 | 14.9 | 12.9 | 12.8 | |
No | 86.8 | 87.6 | 85.1 | 87.1 | 87.2 | |
Hypertension (%) | 0.288 | |||||
Yes | 41.3 | 41.6 | 44.1 | 39.9 | 39.5 | |
No | 58.7 | 58.4 | 55.9 | 60.1 | 60.5 | |
BMI (kg/m2) | 28.24(24.80, 32.43) | 28.22(24.90, 32.30) | 28.80(25.03, 32.82) | 28.28(24.56, 31.95) | 27.62(24.34, 32.32) | 0.133 |
UIC (ug/L) | 151.73(83.10, 259.00) | 159.11(83.10, 273.91) | 136.22(78.50, 244.15) | 158.27(90.38, 261.60) | 151.00(80.91, 264.77) | 0.35 |
eGFR | 92.80(78.52, 103.77) | 89.94(74.56, 101.19) | 92.74(77.29, 103.67) | 94.14(80.43, 104.70) | 94.09(81.01, 105.19) | < 0.001 |
Serum albumin | 4.30(4.10, 4.50) | 4.30(4.10, 4.40) | 4.30(4.10, 4.50) | 4.30(4.10, 4.40) | 4.20(4.00, 4.40) | 0.169 |
Urinary albumin | 7.20 (3.70, 13.70) | 7.40(3.60, 14.90) | 7.61(3.70, 14.10) | 7.30(4.00, 13.10) | 6.50(3.70, 12.90) | 0.822 |
FT3 (pg/mL) | 3.10(2.90, 3.30) | 3.05(2.80, 3.30) | 3.10(2.89, 3.30) | 3.10(2.90, 3.30) | 3.10(2.90, 3.30) | 0.002 |
FT4 (ng/dL) | 10.30(9.00, 11.60) | 10.30(9.00, 11.60) | 10.30(9.00, 11.50) | 10.30(9.00, 11.60) | 10.30(9.00, 11.60) | 0.383 |
TT3 (ng/dL) | 109.00(96.00, 123.00) | 106.00(93.00, 120.00) | 110.00(95.00, 123.00) | 109.00(98.00, 123.00) | 110.00(98.00, 124.00) | 0.004 |
TT4 (ug/dL) | 7.70(6.80, 8.70) | 7.50(6.70, 8.60) | 7.70(6.80, 8.70) | 7.75(6.80, 8.70) | 7.70(6.90, 8.73) | 0.135 |
TSH (mIU/L) | 1.69(1.13, 2.47) | 1.72(1.15, 2.56) | 1.69(1.17, 2.47) | 1.70(1.09, 2.44) | 1.67(1.10, 2.47) | 0.486 |
Tg (ug/L) | 9.94(5.22, 17.70) | 9.69(5.21, 16.76) | 9.55(5.17, 16.50) | 10.34(5.04, 17.71) | 10.10(5.38, 18.95) | 0.594 |
TgAb (IU/mL) | 0.60(0.60, 0.60) | 0.60(0.60, 0.60) | 0.60(0.60, 0.60) | 0.60(0.60, 0.60) | 0.60(0.60, 0.60) | 0.162 |
TPOAb (IU/mL) | 0.63(0.30, 1.80) | 0.60(0.30, 1.70) | 0.62(0.30, 1.80) | 0.70(0.30, 2.00) | 0.60(0.30, 1.90) | 0.059 |