Skip to main content

Table 2 Regression coefficient (β, 95% CI) for changes in log10 serum α-klotho level (pg/mL) in association with thyroid profile, weighted

From: The association between serum soluble α-Klotho and thyroid profile among adults from NHANES 2007–2012

 

Model 1

 

Model 2

 

Model 3

 

β (95%CI)

p-value

β (95%CI)

p-value

β (95%CI)

p-value

 FT3 (pg/mL)

      

 Q1

Reference

 

Reference

 

Reference

 

 Q2

0.051(0.012, 0.090)

0.012

0.041(-0.001, 0.083)

0.055

0.031(-0.011, 0.074)

0.143

 Q3

0.058(0.018, 0.098)

0.006

0.053(0.016, 0.091)

0.006

0.045(0.018, 0.081)

0.018

 Q4

0.063(0.030, 0.097)

< 0.001

0.062(0.031, 0.094)

< 0.001

0.052(0.019, 0.086)

0.003

Per 1 unit increment

0.070(0.032, 0.108)

< 0.001

0.072(0.035, 0.108)

< 0.001

0.063(0.025, 0.101)

0.002

 FT4(ng/dL)

      

 Q1

Reference

 

Reference

 

Reference

 

 Q2

0.005(-0.008, 0.018)

0.460

0.007(-0.006, 0.020)

0.300

0.007(-0.006, 0.020)

0.271

 Q3

0.002(-0.015, 0.019)

0.816

0.005(-0.011,0.020)

0.543

0.005(-0.011, 0.021)

0.541

 Q4

0.012(-0.006, 0.031)

0.188

0.016(-0.002, 0.034)

0.087

0.016(-0.002, 0.035)

0.082

Per 1 unit increment

0.014(-0.006, 0.035)

0.171

0.019(-0.002, 0.039)

0.075

0.019(-0.002, 0.041)

0.073

 TT3 (ng/dL)

      

 Q1

Reference

 

Reference

 

Reference

 

 Q2

3.135(0.601, 5.668)

0.016

2.767(0.071, 5.463)

0.045

2.332(-0.562, 5.226)

0.110

 Q3

4.441(1.659, 7.224)

0.002

4.116(1.516, 6.717)

0.003

3.681(1.069, 6.293)

0.007

 Q4

4.854(2.553, 7.155)

< 0.001

4.528(2.275, 6.781)

< 0.001

4.031(1.666, 6.395)

0.002

Per 1 unit increment

5.470(2.684, 8.255)

< 0.001

5.145(2.491, 7.800)

< 0.001

4.717(1.977, 7.457)

0.001

 TT4 (μg/dL)

      

 Q1

Reference

 

Reference

 

Reference

 

 Q2

0.105(-0.065, 0.275)

0.222

0.121(-0.045, 0.288)

0.148

0.126(-0.048, 0.299)

0.150

 Q3

0.160(-0.044, 0.364)

0.120

0.168(-0.040, 0.377)

0.110

0.176(-0.036, 0.389)

0.100

 Q4

0.194(0.001, 0.387)

0.049

0.192(-0.007, 0.390)

0.058

0.205(0.006, 0.403)

0.044

Per 1 unit increment

0.234(0.001, 0.467)

0.0495

0.225(-0.015, 0.466)

0.066

0.252(0.018, 0.487)

0.036

 TSH (mIU/L)

      

 Q1

Reference

 

Reference

 

Reference

 

 Q2

-0.075(-0.269, 0.119)

0.439

-0.068(-0.262, 0.126)

0.482

-0.058(-0.252, 0.136)

0.546

 Q3

-0.035(-0.493,0.423)

0.879

-0.021(-0.471, 0.428)

0.925

0.020(-0.434, 0.474)

0.928

 Q4

-0.181(-0.353, -0.008)

0.041

-0.169(-0.339, 0.001)

0.051

-0.139(-0.312, 0.034)

0.112

Per 1 unit increment

-0.285(-0.511, -0.058)

0.015

-0.274(-0.500, − 0.047)

0.019

-0.230(-0.459, -0.002)

0.048

 Tg (ug/L)

      

 Q1

Reference

 

Reference

 

Reference

 

 Q2

-3.914(-9.939, 2.110)

0.197

-3.703(-9.666, 2.260)

0.217

-3.714 (-9.783, 2.355)

0.222

 Q3

-1.598(-7.013, 3.817)

0.555

-1.655(-7.160, 3.850)

0.547

-1.505 (-7.200, 4.190)

0.594

 Q4

-0.906(-6.787, 4.975)

0.758

-1.142(-7.249, 4.965)

0.708

-0.891(-7.099, 5.381)

0.772

Per 1 unit increment

0.674(-5.172, 6.520)

0.818

0.275(-5.909, 6.458)

0.929

0.832(-5.353, 7.017)

0.786

 TgAb (IU/mL)

      

 Q1

Reference

 

Reference

 

Reference

 

 Q2

-1.086(-9.058, 6.885)

0.785

-0.502(-8.576, 7.536)

0.897

-0.159(-8.113, 7.795)

0.968

 Q3

-0.483(-9.606, 8.641)

0.916

0.110(-8.842, 9.062)

0.980

0.499(-8.304, 9.302)

0.909

 Q4

4.062(-7.607, 15.732)

0.487

4.67(-6.960, 16.300)

0.423

4.906(-6.280, 16.091)

0.378

Per 1 unit increment

5.262(-11.442, 21.966)

0.529

5.924(-10.277, 22.126)

0.465

6.190(-9.742, 22.122)

0.435

 TPOAb (IU/mL)

      

 Q1

Reference

 

Reference

 

Reference

 

 Q2

2.195(-10.429, 14.820)

0.728

2.304(-10.204, 14.812)

0.712

2.511(-9.721, 14.744)

0.679

 Q3

-2.608(-12.648, 7.433)

0.604

-3.122(-13.400, 7.157)

0.543

-2.858(-12.991, 7.275)

0.510

 Q4

1.815(-9.715, 13.345)

0.753

0.419(-11.365, 12.202)

0.943

0.634(-11.007, 12.276)

0.912

Per 1 unit increment

-1.965(-12.609, 8.678)

0.712

-4.010(-15.407, 7.388)

0.482

-3.623(-14.775, 7.529)

0.514

  1. Log10 serum α-klotho level was converted from a continuous variable to a categorical variable (quartiles). Q1: 5.05–6.49, Q2: 6.49–6.69, Q3: 6.49–6.9, Q4: 6.9–8.15
  2. Model 1: unadjusted;
  3. Model 2: age, race and gender were adjusted;
  4. Model 3: age, race, gender, UIC, annual family income, smoking, diabetes, hypertension, BMI, education, marital status, eGFR, serum albumin levels and urinary albumin levels were adjusted
  5. Abbreviations: UIC: urine iodine concentration; BMI: body mass index; FT3: free triiodothyronine; FT4: free thyroxine; TT3: total T3; TT4: total T4; TSH: thyroid-stimulating hormone; Tg: Thyroglobulin; TgAb: Thyroglobulin antibodies; TPOAb: Thyroid peroxidase antibodies; eGFR: estimated glomerular filtration rate
Back to article page

BMC Endocrine Disorders

ISSN: 1472-6823

Contact us