Table 3 Subgroup analysis of the relationship between serum log10 α-klotho level (pg/mL) and thyroid profile, weighted
β (95%CI), p-value | ||||||||
|---|---|---|---|---|---|---|---|---|
Free T3 (pg/mL) | Free T4(ng/dL) | Total T3 (ng/dL) | Total T4 (μg/dL) | TSH (mIU/L) | Tg (ug/L) | TgAb (IU/mL) | TPOAb (IU/mL) | |
Age | ||||||||
>=50 | 0.056(0.006,0.106) 0.029 | 0.012(-0.011,0.034) 0.301 | 4.536(1.846,7.226) 0.001 | 0.194(-0.054,0.442) 0.123 | -0.250(-0.599,0.099) 0.156 | -0.287(-9.131,8.557) 0.948 | 9.620(-13.859,33.100) 0.414 | 0.674(-12.557,13.905) 0.919 |
< 50 | 0.076(-0.004,0.155) 0.061 | 0.033(-0.001,0.068) 0.067 | 5.123(0.225,10.022) 0.041 | 0.358(-0.047,0.762) 0.082 | -0.239(-0.612,0.134) 0.204 | 3.050(-2.263,8.793) 0.291 | -2.559(-7.962,2.845) 0.346 | -12.293(-28.887,4.300) 0.143 |
Gender | ||||||||
Male | 0.068(0.018,0.119) 0.009 | 0.010(-0.024,0.045) 0.551 | 6.243(2.801,9.686) < 0.001 | 0.276(-0.033,0.585) 0.079 | -0.001(-0.271,0.269) 0.993 | -1.313(-7.109,4.482) 0.651 | 4.036(-8.863,16.934) 0.532 | -0.491(-12.884,11.903) 0.937 |
Female | 0.058(0.017,0.098) 0.007 | 0.026(-0.002,0.054) 0.072 | 3.440(-0.025,6.904) 0.052 | 0.245(-0.117, 0.606) 0.180 | -0.426(-0.730, -0.121) 0.007 | 2.426(-7.623,12.475) 0.630 | 7.488(-18.990,33.965) 0.572 | -7.089(-21.943,7.764) 0.342 |
UIC | ||||||||
Deficient | 0.036(-0.034,0.107) 0.305 | 0.015(-0.026,0.056) 0.461 | 5.590(0.609,10.571) 0.029 | 0.012(-0.422,0.446) 0.956 | -0.099(-0.362, 0.164) 0.451 | 3.818(-2.068,9.704) 0.199 | -15.969(-33.597,1.660) 0.075 | -2.073(-18.535,14.389) 0.801 |
Normal | 0.074(0.037,0.112) < 0.001 | 0.021(-0.008,0.051) 0.156 | 5.255(2.039,8.471) 0.002 | 0.343(-0.010,0.670) 0.057 | -0.419(-0.801, -0.038) 0.032 | -1.082(-13.384,11.220) 0.860 | 20.412(-11.954,52.777) 0.211 | 0.084(-14.217,14.385) 0.991 |
Excessive | 0.076(-0.012,0.163) 0.087 | 0.022(-0.023,0.067) 0.324 | 2.093(-2.050,6.235) 0.315 | 0.482 (0.013,0.951) 0.044 | -0.126(-0.628,0.377) 0.618 | 0.153(-9.887,10.193) 0.976 | 3.140(-12.985,19.264) 0.697 | -13.718(-44.141,16.705) 0.369 |
BMI | ||||||||
Underweight | -0.118(-0.416,0.180) 0.423 | 0.075(-0.125,0.275) 0.447 | 3.137 (-19.322,25.596) 0.777 | -0.194(-2.427,2.040) 0.860 | -0.179(-1.316,0.959) 0.750 | -28.897(-56.634, -1.160) 0.042 | 0.791(-5.112,6.695) 0.786 | -0.879(-69.984,78.226) 0.982 |
Normal weight | 0.026(-0.033,0.850) 0.386 | 0.013(-0.024,0.051) 0.484 | 3.988(-0.936,8.913) 0.110 | 0.205(-0.330,0.741) 0.445 | -0.366(-0.937,0.205) 0.203 | 2.007(-1.948,5.963) 0.313 | 24.734(-26.959,76.428) 0.341 | -8.230(-24.618,8.158) 0.318 |
Overweight | 0.069(0.002,0.137) 0.045 | 0.021(-0.008,0.050) 0.157 | 4.720(1.009,8.430) 0.014 | 0.304(-0.006,0.614) 0.054 | -0.176(-0.467,0.115) 0.230 | 4.030(0.081,7.980) 0.046 | -1.475(-15.350,12.400) 0.832 | 7.817(-8.372,24.005) 0.337 |
Obese | 0.097(0.055,0.140) < 0.001 | 0.019(-0.015,0.053) 0.259 | 5.579(1.576,9.581) 0.007 | 0.247(-0.038,0.532) 0.088 | -0.133(-0.469,0.203) 0.430 | -2.853(-20.483,14.776) 0.746 | -0.115(-16.229,16.000) 0.989 | -10.262(-31.304,10.780) 0.332 |