Table 3 Genotype and allele frequencies of rs2295080 polymorphism in type 2 diabetic patients and healthy controls
SNP | Patients (n = 109) N (%) | Controls (n = 375) N (%) | OR (95%CI) | p-value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | Male | Female | Total | Male | Female | Total | Male | Female | Total | Male | Female | ||
rs2295080 | |||||||||||||
Genotypes | TT | 52 (47.7) | 28 (49.5) | 24 (46.0) | 184 (49.0) | 106 (50.0) | 78 (48.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
GT | 42 (38.3) | 22 (38.5) | 20 (38.5) | 139 (37.0) | 87 (41.0) | 52 (32.0) | 1.1 0.3–3.1 | 1.04 0.2–4.1 | 1.36 0.2–7.3 | 0.85 | 0.95 | 0.71 | |
GG | 15 (14.0) | 7 (12.0) | 8 (15.5) | 52 (14.0) | 20 (9.0) | 32 (20.0) | 0.01 0.02–0.4 | 0.01 0.04–0.2 | 0.01 0.02–0.45 | 0.99 | 0.99 | 0.99 | |
Alleles | T | 145 (66.5) | 78 (68.0) | 67 (64.5) | 507 (67.0) | 299 (70.0) | 208 (64.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 73 (33.5) | 36 (32.0) | 37 (35.5) | 243 (33.0) | 127 (30.0) | 116 (36.0) | 1.79 0.75–4.2 | 1.3 0.42–4.2 | 1.7 0.4–6.8 | 0.18 | 0.63 | 0.44 | |
Genotype combination | TT | 52 (47.7) | 28 (49.0) | 24 (46.0) | 184 (49.0) | 106 (49.7) | 78 48.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
GT + GG | 57 (52.3) | 29 (51.0) | 28 (54.0) | 191 (51.0) | 107 (50.3) | 84 (52.0) | 1.3 0.4–3.7 | 1.1 0.2–4.4 | 1.1 0.19–6.1 | 0.6 | 0.8 | 0.9 | |
GG | 15 (14.0) | 7 (12.0) | 8 (15.0) | 52 (14.0) | 20 (9.0) | 32 (19.7) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
GT + TT | 94 (86.0) | 50 (88.0) | 44 (85.0) | 323 (86.0) | 193 (91.0) | 130 (80.3) | 1.7 0.01–0.2 | 9.7 0.01–0.1 | 1.7 0.6–1.09 | 0.99 | 0.99 | 0.99 | |