Fig. 6

The mechanism of AGEs involving in lipids disorder via SREBP-1c. Notes: The interaction between AGEs and its receptor, RAGE, initiates phosphorylation events involving p65 nfκb and p38 MAPK. The phosphorylation of these signaling molecules contributes to subsequent processing of the SREBP-1c precursor into its mature form, thereby culminating in dysregulation of lipid metabolism