Table 2 Association between sNfL levels and type 2 DM and their combined effect on all-cause mortality

sNfL levels

 Continuous sNfL

3.21(2.47,4.18)

< 0.001

3.04(2.14,4.33)

< 0.001

 Not elevated

1 [Reference]

1 [Reference]

 Elevated

5.60(2.50,12.53)

< 0.001

4.38(2.04,9.39)

< 0.001

type 2 DM

 No

1 [Reference]

1 [Reference]

 Yes

3.13(1.48,6.60)

0.003

2.49(1.23,5.05)

0.011

sNfL and type 2 DM

 No type 2 DM

1 [Reference]

1 [Reference]

 type 2 DM and not elevated

1.25(0.50, 3.11)

0.626

1.14(0.45,2.93)

0.778

 type 2 DM and elevated

5.10(2.39,10.89)

< 0.001

3.79(1.88,7.65)

< 0.001