Association of free fatty acid in first trimester with the risk of gestational diabetes mellitus: a nested case-control study

Table 3 Joint effect of weighted FFA risk scores and GDM^a

FFA Risk Score	FFA Risk Score	GDM	Control	OR(95%CI)	P
SFA Risk Score^b	MUFA Risk Score
-	-	7	47	Ref-	-
-	+	9	12	6.21(1.46–26.49)	0.0136
+	-	5	16	2.03(0.46–8.90)	0.3499
+	+	29	25	9.55(2.84–32.05)	0.0003
SFA Risk Score	PUFA Risk Score
-	-	6	37	Ref-	-
-	+	10	22	3.26(0.77–13.83)	0.1084
+	-	12	20	4.09(0.94–17.79)	0.0608
+	+	22	21	6.45(1.81–23.00)	0.0041
SFA Risk Score	TFA Risk Score
-	-	10	43	Ref-	-
-	+	6	16	1.78(0.44–7.10)	0.4171
+	-	10	12	3.77(0.97–14.62)	0.0553
+	+	24	29	3.46(1.19–10.08)	0.0227
MUFA Risk Score	PUFA Risk Score
-	-	8	45	Ref-	-
-	+	4	18	0.76(0.15–3.86)	0.7412
+	-	10	12	4.44(1.05–18.74)	0.0426
+	+	28	25	6.46(2.02–20.61)	0.0016
MUFA Risk Score	TFA Risk Score
-	-	7	44	Ref-	-
-	+	5	19	1.59(0.34–7.31)	0.5531
+	-	13	11	16.62(3.28–84.09)	0.0007
+	+	25	26	6.81(1.96–23.69)	0.0025
PUFA Risk Score	TFA Risk Score
-	-	7	36	Ref-	-
-	+	11	21	1.94(0.53–7.08)	0.3144
+	-	13	19	2.77(0.85–9.06)	0.0916
+	+	19	24	3.68(1.13–11.95)	0.0303
SFA Risk Score	UFA Risk Score
-	-	6	42	Ref-	-
-	+	10	17	6.37(1.33–30.53)	0.0206
+	-	9	18	4.25(0.97–18.70)	0.0555
+	+	25	23	8.53(2.41–30.24)	0.0009

^a FFA risk score was calculated in the way described in the method part and median and joint effect analysis was performed; results were adjusted for exercise after pregnancy and weight gain from pregnancy to gestational age of week 24, fiber intake frequency score, carbohydrate intake frequency score, protein intake frequency score, supplement intake and history of diabetes
^b “+” means FFA risk score was higher than the median of the corresponding FFA risk score, and “-” means the FFA risk score was lower than the median of the corresponding FFA risk score
^c TFAs were excluded when calculating the risk score

ISSN: 1472-6823