Gender differences in the relationship between the triglyceride-glucose index and serum Klotho concentrations among the middle-aged and elderly: a cross-sectional analysis

Table 2 Multivariate linear analysis of the association between TyG index and serum Klotho concentrations

Exposure	Model 1 β (95% CI)	P-value	Model 2 β (95% CI)	P-value	Model 3 β (95% CI)	P-value
Female group
TyG index	-75.48 (-92.72, -58.24)	< 0.0001	-68.29 (-85.84, -50.74)	< 0.0001	-83.41 (-124.23, -42.60)	< 0.0001
TyG index quartiles
Quartile 1	Reference		Reference		Reference
Quartile 2	-53.89 (-82.70, -25.08)	0.0002	-48.13 (-76.83, -19.44)	0.0010	-29.99 (-81.57, 21.59)	0.2547
Quartile 3	-93.00 (-122.40, -63.60)	< 0.0001	-82.61 (-112.30, -52.93)	< 0.0001	-85.61 (-145.58, -25.65)	0.0052
Quartile 4	-123.32 (-153.26, -93.39)	< 0.0001	-111.29 (-141.64, -80.93)	< 0.0001	-88.77 (-155.58, -21.95)	0.0093
P for trend	< 0.0001		< 0.0001		0.0041
Male group
TyG index	19.78 (4.24, 35.32)	0.0126	18.48 (2.79, 34.16)	0.0210	15.40 (-19.16, 49.95)	0.3827
TyG index quartiles
Quartile 1	Reference		Reference		Reference
Quartile 2	28.14 (0.49, 55.79)	0.0462	26.96 (-0.75, 54.68)	0.0566	-7.95 (-56.31, 40.40)	0.7473
Quartile 3	22.88 (-4.75, 50.51)	0.1047	22.30 (-5.44, 50.05)	0.1152	-27.30 (-77.86, 23.27)	0.2903
Quartile 4	34.73 (6.90, 62.57)	0.0145	32.39 (4.29, 60.48)	0.0239	11.76 (-45.69, 69.20)	0.6884
P for trend	0.0275		0.0423		0.8620

Model 1: No covariates were adjusted
Model 2: Age and race were adjusted
Model 3: Age, race, PIR, BMI, waist circumference, education, smoking, alcohol consumption, HDL-C, LDL-C, eGFR, cancer, stroke, CHF, CHD, angina, heart attack, COPD, hypoglycemic drugs or insulin use, lipid-lowering drug use, diabetes, and hypertension were adjusted
BMI: Body mass index; PIR: Poverty income ratio; CHF: Congestive heart failure; CHD: Coronary heart disease; COPD: Chronic obstructive pulmonary disease; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; eGFR: Estimated glomerular filtration rate

ISSN: 1472-6823