Table 1 MR analysis using SNPs at the locus-wide significance level

Phylum

Bacteroidetes

10

1.58 (1.15, 2.17)

5.17E-03

0.01

0.78

0.37

9.81

0.37

stable

Class

Bacteroidia

13

1.56 (1.17, 2.09)

2.57E-03

-0.01

0.77

0.37

13.53

0.33

stable

Class

Verrucomicrobiae

10

1.46 (1.14, 1.87)

2.91E-03

0.04

0.31

0.66

6.95

0.64

stable

Order

Bacteroidales

13

1.56 (1.17, 2.09)

2.57E-03

-0.01

0.77

0.35

13.53

0.33

stable

Order

Verrucomicrobiales

10

1.46 (1.14, 1.87)

2.91E-03

0.04

0.31

0.68

6.95

0.64

stable

Order

Rhodospirillales

14

1.20 (1.01, 1.43)

4.44E-02

-0.05

0.20

0.53

12.03

0.53

unstable

Order

Burkholderiales

9

0.73 (0.53, 0.99)

4.89E-02

-0.03

0.38

0.62

6.42

0.60

unstable

Family

Verrucomicrobiaceae

10

1.46 (1.14, 1.87)

2.92E-03

0.04

0.30

0.68

6.95

0.64

stable

Genus

Akkermansia

10

1.46 (1.14, 1.87)

2.91E-03

0.04

0.31

0.65

6.95

0.64

stable

Genus

Coprococcus2

8

0.68 (0.51, 0.91)

9.63E-03

0.01

0.88

0.64

5.29

0.63

stable

Genus

Catenibacterium

4

1.33 (1.07, 1.66)

9.81E-03

-0.13

0.55

0.88

0.76

0.86

stable

Genus

Eubacterium_coprostanoligenes_group

13

0.69 (0.52, 0.92)

1.03E-02

0.05

0.15

0.65

10.07

0.61

stable

Genus

Lachnospiraceae_UCG001

11

1.27 (1.02, 1.57)

2.94E-02

-0.03

0.51

0.94

4.44

0.93

unstable

Genus

Lachnoclostridium

11

1.37 (1.02, 1.84)

3.37E-02

-0.01

0.80

0.64

8.35

0.59

unstable

Genus

Parasutterella

13

1.23 (1.01, 1.50)

4.01E-02

0.01

0.52

0.89

6.35

0.90

unstable

Genus

Ruminococcaceae_UCG014

10

0.75 (0.58, 0.96)

2.22E-02

0.00

0.91

0.99

2.32

0.99

unstable

Genus

Streptococcus

10

1.39 (1.03, 1.88)

3.39E-02

0.01

0.87

0.65

7.52

0.58

unstable