Association between gut microbiota and diabetic nephropathy: a two-sample mendelian randomization study

BMC Endocrine Disorders

Table 3 Reverse MR analysis using SNPs associated with diabetic nephropathy at the genome-wide significance level

Taxa	Gut bacteria	nSNP	MR results		Horizontal pleiotropy			Heterogeneity		Sensitivity
Taxa	Gut bacteria	nSNP	OR (95% CI)	P value	Intercept	P value	MR_PRESSO^a	Q statistic	P value	Sensitivity
Phylum	Bacteroidetes	7	1.00 (0.97, 1.03)	0.93	0.02	0.13	0.33	8.00	0.24	stable
Class	Bacteroidia	7	1.00 (0.97, 1.04)	0.86	0.02	0.16	0.32	8.08	0.23	stable
Class	Verrucomicrobiae	7	1.02 (0.97, 1.07)	0.46	0.01	0.53	0.21	11.57	0.07	stable
Order	Bacteroidales	7	1.00 (0.97, 1.03)	0.86	0.02	0.16	0.33	8.08	0.23	stable
Order	Burkholderiales	7	0.99 (0.96, 1.02)	0.54	0.01	0.34	0.87	2.97	0.81	stable
Order	Rhodospirillales	7	1.04 (0.99, 1.08)	0.09	0.01	0.95	0.51	5.79	0.45	unstable
Order	Verrucomicrobiales	7	1.02 (0.97, 1.07)	0.46	0.01	0.53	0.21	11.57	0.07	stable
Family	Oxalobacteraceae	6	1.00 (0.95, 1.06)	0.90	-0.01	0.58	0.73	2.05	0.84	unstable
Family	Verrucomicrobiaceae	7	1.02 (0.97, 1.07)	0.46	0.01	0.53	0.20	11.56	0.07	stable
Genus	Akkermansia	7	1.02 (0.97, 1.07)	0.47	0.01	0.53	0.24	11.48	0.07	stable
Genus	Catenibacterium	5	1.04 (0.97, 1.12)	0.29	0.01	0.92	0.99	0.22	0.99	stable
Genus	Coprococcus2	7	1.00 (0.96, 1.04)	0.87	-0.01	0.43	0.73	3.46	0.75	stable
Genus	Eubacterium_coprostanoligenes_group	7	1.01 (0.98, 1.04)	0.35	-0.01	0.44	0.62	4.46	0.61	stable
Genus	Lachnoclostridium	7	0.99 (0.97, 1.03)	0.88	-0.01	0.53	0.82	1.98	0.92	stable
Genus	Lachnospiraceae_UCG001	7	1.00 (0.96, 1.04)	0.60	0.01	0.42	0.53	5.95	0.43	stable
Genus	Parasutterella	7	1.01 (0.98, 1.05)	0.41	0.01	0.98	0.89	2.82	0.83	stable
Genus	Ruminococcaceae_UCG014	7	0.98 (0.95, 1.01)	0.26	0.01	0.58	0.68	4.64	0.59	stable
Genus	Streptococcus	7	1.05 (1.00, 1.09)	0.02	-0.02	0.15	0.26	10.40	0.11	unstable

^aP value of MR_PRESSO global test; OR, odds ratio; CI, Confidence interval; nSNP, number of single nucleotide polymorphism

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