Does higher serum 25-hydroxyvitamin D levels will harm bone mineral density?: a cross-sectional study

Xu, Bingcheng; Li, Qiai; Luo, Bo; Liu, Hao

doi:10.1186/s12902-024-01760-9

BMC Endocrine Disorders

Table 3 Relationship between 25(OH)D(nmol/L) and total BMD(g/cm²)

From: Does higher serum 25-hydroxyvitamin D levels will harm bone mineral density?: a cross-sectional study

	Crude model		Model I		Model II
	β (95%CI)	P-value	β (95%CI)	P-value	β (95%CI)	P-value
25(OH)D(nmol/L)	-0.0001 (-0.0002, -0.0000)	0.033972	0.0003 (0.0002, 0.0004)	< 0.000001	0.0003 (0.0003, 0.0004)	< 0.000001
25(OH)D (nmol/L) (continuous)
Q1, <47.9	Reference		Reference		Reference
Q2, ≥ 47.9 to <67.9	-0.0060 (-0.0113, -0.0007)	0.025534	0.0068 (0.0017, 0.0118)	0.008376	0.0072 (0.0022, 0.0121)	0.004411
Q3, ≥ 67.9	0.0007 (-0.0043, 0.0057)	0.791956	0.0217 (0.0166, 0.0267)	< 0.000001	0.0241 (0.0190, 0.0291)	< 0.000001
P value for trend	< 0.001		< 0.001		< 0.001
Stratified by Gender
Male	0.0003 (0.0002, 0.0004)	< 0.0001	0.0006 (0.0005, 0.0007)	< 0.0001	0.0006 (0.0005, 0.0008)	< 0.0001
Female	-0.0001 (-0.0002, -0.0000)	0.0183	0.0001 (-0.0000, 0.0002)	0.1776	0.0001 (0.0000, 0.0002)	0.0049
Stratified by Age (year)
18-39.9	-0.0001 (-0.0002, 0.0000)	0.1076	0.0003 (0.0002, 0.0004)	< 0.0001	0.0004 (0.0002, 0.0005)	< 0. 0001
40–59	-0.0000 (-0.0001, 0.0001)	0.9917	0.0003 (0.0001, 0.0004)	0.0003	0.0003 (0.0002, 0.0004)	< 0. 0001
Stratified by Race
Mexican American	0.0003 (0.0000, 0.0005)	0.0248	0.0003 (0.0001, 0.0005)	0.0088	0.0004 (0.0002, 0.0007)	0.0002
Other Hispanic	0.0001 (-0.0002, 0.0004)	0.3865	0.0003 (0.0000, 0.0005)	0.0443	0.0003 (0.0001, 0.0006)	0.0164
Non-Hispanic White	0.0000 (-0.0001, 0.0002)	0.5193	0.0003 (0.0002, 0.0004)	< 0.0001	0.0004 (0.0002, 0.0004)	< 0.0001
Non-Hispanic Black	-0.0001 (-0.0003, 0.0001)	0.4193	0.0002 (-0.0000, 0.0004)	0.0884	0.0003 (0.0001, 0.0005)	0.0034
Other Race - Including Multi-Racial	0.0002 (-0.0000, 0.0004)	0.0680	0.0004 (0.0002, 0.0006)	< 0.0001	0.0004 (0.0002, 0.0006)	< 0.0001

Data were presented as β(95%CI) P value
Abbreviations: 25(OH)D = 25-hydroxyvitamin D. BMD = Bone Mineral Density. BMI = Body Mass Index
Model I adjusted for gender, age, and race
Model II adjusted for gender, age, race, education level, family income to poverty ratio, body mass index, alcohol consumption frequency, serum cotinine, physical activity, sedentary activity, Sun Exposure, and HbA1C
In the stratified analysis stratified by gender, age, race, and BMI, the model is not adjusted for gender, age, and race, respectively

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ISSN: 1472-6823

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