Lipids as the link between central obesity and diabetes: perspectives from mediation analysis

BMC Endocrine Disorders

Table 5 Mediation analysis for waist circumference and diabetes via lipid parameters in the whole population

Mediator	Total effect	Mediation effect	Direct effect	PM(%)	p-value of PM
TC	0.010 (0.006, 0.015)	-0.001 (-0.001, 0.000)	0.010 (0.006, 0.015)	-	-
TG	0.010 (0.006, 0.015)	0.002 (0.001, 0.002)	0.008 (0.004, 0.013)	15.9	< 0.001
HDL-C	0.010 (0.006, 0.015)	0.003 (0.002, 0.004)	0.007 (0.003, 0.012)	27.6	< 0.001
LDL-C	0.010 (0.006, 0.015)	-0.000 (-0.001, 0.000)	0.010 (0.006, 0.015)	-	-
Non-HDL-C	0.010 (0.006, 0.015)	-0.000 (-0.001, 0.000)	0.010 (0.006, 0.015)	-	-
RC	0.010 (0.006, 0.015)	0.001 (0.000, 0.002)	0.009 (0.005, 0.014)	9	0.024
TC/HDL-C ratio	0.010 (0.006, 0.015)	0.003 (0.002, 0.004)	0.007 (0.003, 0.012)	30.7	< 0.001
TG/HDL-C ratio	0.010 (0.006, 0.015)	0.003 (0.002, 0.003)	0.007 (0.003, 0.012)	25.6	< 0.001
LDL/HDL-C ratio	0.010 (0.006, 0.015)	0.003 (0.002, 0.004)	0.007 (0.003, 0.012)	28.6	< 0.001
Non-HDL/HDL-C ratio	0.010 (0.006, 0.015)	0.003 (0.002, 0.004)	0.007 (0.003, 0.012)	30.7	< 0.001
RC/HDL-C ratio	0.010 (0.006, 0.015)	0.004 (0.003, 0.005)	0.006 (0.002, 0.011)	36.8	< 0.001

Abbreviations: PM: propotion mediate; other abbreviations as in Table 1
Adjusting variables: sex, age, height, fatty liver, habit of exercise, smoking status and drinking status, SBP, FPG, HbA1c, ALT, AST and GGT

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