Table 2 Statistical differences between thyroid function subgroups (hypothyroidism, normal thyroid function, and thyrotoxicosis)
Hypothyroidism (n = 26) | Normal thyroid function (n = 346) | Thyrotoxicosis (n = 37) | p value | |
|---|---|---|---|---|
Age (years) | 52.0 ± 15.9 | 56.9 ± 17.7 | 55.7 ± 15.3 | 0.39 |
Sex - male [n (%)] | 3 (11.5%) | 34 (9.8%) | 3 (8.1%) | 0.90 |
BMI (kg/m²) | 29.7 ± 7.9 | 28.0 ± 5.5 | 29.2 ± 5.9 | 0.44 |
Dyslipidemia [n (%)] | 20 (80.0%) | 214 (63.7%) | 19 (52.8%) | 0.09 |
Diabetes [n (%)] | 7 (26.9%) | 103 (30.2%) | 9 (24.3%) | 0.73 |
Levothyroxine [n (%)] | 19 (95.0%) | 221 (79.8%) | 26 (89.7%) | 0.12 |
TSH (µUI/mL) | 11.1 ± 8.3 | 1.8 ± 1.1 | 0.2 ± 0.1 | < 0.001 |
FT4 (ng/dL) | 1.1 ± 0.2 | 1.1 ± 0.7 | 1.3 ± 0.3 | 0.28 |
FT3 (pg/mL) | 2.5 ± 0.4 | 2.7 ± 0.5 | 2.9 ± 0.6 | 0.039 |
TPOab (UI/mL) | 258.5 [21.6, 756.0] | 33.3 [1.1, 208.0] | 18.1 [1.4, 172.3] | 0.013 |
Tgab (UI/mL) | 15.9 [2.8, 222.6] | 13.1 [2.8, 55.6] | 10.5 [1.6, 40.8] | 0.36 |
TC (mg/dL) | 197.6 ± 40.4 | 185.4 ± 38.0 | 182.7 ± 43.9 | 0.28 |
LDL (mg/dL) | 112.7 ± 34.0 | 106.0 ± 32.5 | 107.2 ± 33.6 | 0.62 |
HDL (mg/dL) | 58.6 ± 14.7 | 57.0 ± 15.7 | 62.0 ± 35.3 | 0.28 |
Triglycerides (mg/dL) | 118.0 [80.0, 182.5] | 98.0 [73.0, 133.0] | 85.0 [66.0, 129.0] | 0.12 |
Hemoglobin A1c (%) | 5.7 ± 1.0 | 5.8 ± 0.8 | 5.8 ± 0.9 | 0.80 |
Fasting glucose (mg/dL) | 86.7 ± 11.4 | 96.9 ± 31.2 | 102.4 ± 28.0 | 0.13 |
CRP (mg/L) | 2.4 ± 2.1 | 4.8 ± 14.2 | 3.3 ± 4.5 | 0.76 |
Folic acid | 7.3 ± 4.1 | 7.4 ± 4.3 | 7.9 ± 4.7 | 0.84 |
Dimensions [n (%)] | 0.003 | |||
- Decreased | 6 (26.1%) | 68 (21.6%) | 16 (50.0%) | |
- Normal | 15 (65.2%) | 206 (65.4%) | 10 (31.2%) | |
- Increased | 2 (8.7%) | 41 (13.0%) | 6 (18.8%) | |
Nodular pattern [n (%)] | 0.003 | |||
- Any | 19 (82.6%) | 145 (45.3%) | 20 (62.5%) | |
- Uninodular | 2 (8.7%) | 68 (21.2%) | 2 (6.2%) | |
- Multinodular | 2 (8.7%) | 107 (33.4%) | 10 (31.2%) | |
Thyroid volume (mL) | 9.6 ± 9.7 | 10.3 ± 9.1 | 10.3 ± 9.4 | 0.94 |