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Table 3 Association of TIR and other glycemic metrics with cognitive impairment in patients with T2DM

From: Association of time in range with cognitive impairment in middle-aged type 2 diabetic patients

 

OR per increase of

Unadjusted

 

Model 1

 

Model 2

 

Model 3

 

Model 4

  

OR (95%CI)

 

OR (95%CI)

 

OR (95%CI)

 

OR (95%CI)

 

OR (95%CI)

TIR

10%

0.88 (0.81–0.96)#

 

0.85 (0.77–0.93)#

 

0.84 (0.76–0.92)#

 

0.84 (0.76–0.93)#

 

0.83 (0.75–0.92)#

TAR

10%

1.12 (1.03–1.22)#

 

1.16 (1.06–1.28)#

 

1.18 (1.07–1.29)#

 

1.17 (1.06–1.29)#

 

1.19 (1.08–1.31)#

HbA1c

1%

0.93 (0.82–1.05)

 

0.95 (0.84–1.08)

 

0.95 (0.84–1.09)

 

0.92 (0.80–1.06)

 

0.95 (0.84–1.09)

  1. TIR, time in range; TAR, time above range; HbA1c, hemoglobin A1c
  2. aModel 1: adjusted for age, education, marital status; Model 2: Model 1 + age at DM onset and cerebrovascular disease (CVD). Model 3 :Model 2 + SD. Model 4:Model 2 + CV
  3. *ORs and P values were estimated for each 10% increase in TIR (0–100%) and TAR (0–100%), and each 1% increase in HbA1c.OR: odds ratio, 95% CI: 95% confidence interval
  4. *p value<0.05, #p value<0.01
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BMC Endocrine Disorders

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