Table 1 The demographic information and baseline characteristics of all groups
Variables | Total | Overt hypothyroidism | Subclinical hypothyroidism | Euthyroid | Subclinical hyperthyroidism | Overt hyperthyroidism | p-value |
|---|---|---|---|---|---|---|---|
Number (%) | 6507 (100) | 21 (0.32) | 467 (7.18) | 5805 (89.21) | 156 (2.40) | 58 (0.89) | |
Age, mean (SD) | 58.52 (16.30) | 65.76 (15.36) | 64.83 (14.97) | 57.75 (16.29) | 62.92 (14.93) | 70.59 (13.01) | < 0.001 |
Gender, N (%) | |||||||
Male | 3102 (47.67) | 12 (57.14) | 185 (39.61) | 2834 (48.82) | 62 (39.74) | 9 (15.52) | < 0.001 |
Female | 3405 (52.33) | 9 (42.86) | 282 (60.39) | 2971 (51.18) | 94 (60.26) | 49 (84.48) | |
1.30–3.49 | 2333 (35.85) | 10 (47.62) | 251 (53.75) | 1975 (34.00) | 73 (46.80) | 24 (41.38) | |
≥ 3.50 | 2274 (34.95) | 9 (42.86) | 113 (24.20) | 2089 (35.99) | 35 (22.44) | 28 (48.28) | |
Smoking, N (%) | |||||||
Never smoker | 3687 (56.66) | 0 (0) | 257 (55.03) | 3308 (56.98) | 92 (58.98) | 30 (51.72) | < 0.001 |
Past smoker | 1293 (19.87) | 0 (0) | 98 (20.98) | 1161 (20.00) | 23 (14.74) | 11 (18.96) | |
Current smoker | 1527 (23.47) | 21 (100) | 112 (23.99) | 1336 (23.02) | 41 (26.28) | 17 (29.31) | |
BMI (kg/m²), mean (SD) | 29.59 (6.71) | 31.55 (9.23) | 30.49 (7.85) | 29.59 (6.65) | 28.00 (4.85) | 26.48 (4.48) | < 0.001 |
SBP (mmHg), mean (SD) | 129.44 (20.97) | 118.57 (23.77) | 132.43 (21.76) | 129.14 (20.63) | 132.07 (26.20) | 132.00 (28.06) | < 0.001 |
DBP (mmHg), mean (SD) | 68.38 (14.75) | 69.33 (10.15) | 67.49 (12.03) | 68.70 (14.71) | 63.07 (17.53) | 57.46 (23.01) | < 0.001 |
Glucose, plasma (mg/dL), mean (SD) | 120.87 (50.82) | 118.28 (27.37) | 127.47 (55.87) | 120.22 (49.69) | 130.45 (78.23) | 108.36 (12.09) | 0.002 |
Direct HDL-Cholesterol (mg/dL), mean (SD) | 53.02 (15.76) | 48.19 (10.75) | 52.37 (16.32) | 53.11 (15.84) | 53.20 (12.54) | 50.94 (12.95) | < 0.001 |
Triglyceride (mg/dL), mean (SD) | 150.92 (134.98) | 177.61 (61.91) | 160.29 (91.87) | 151.19 (139.72) | 124.23 (75.60) | 110.87 (41.71) | 0.011 |
METS-IR, mean (SD) | 45.14 (12.56) | 48.69 (11.25) | 47.35 (14.77) | 45.09 (12.43) | 42.13 (9.95) | 39.69 (8.80) | < 0.001 |
HTN, N (%) | |||||||
Yes | 3535 (94.34) | 20 (100) | 251 (92.62) | 3124 (94.29) | 100 (97.09) | 40 (100) | 0.003 |
No | 212 (5.66) | 0 (0) | 20 (7.38) | 189 (5.71) | 3 (2.91) | 0 (0) | |
HLP, N (%) | |||||||
Yes | 2551 (82.05) | 0 (0) | 130 (75.15) | 2324 (82.85) | 78 (79.59) | 19 (61.29) | < 0.001 |
No | 558 (17.95) | 2 (100) | 43 (24.85) | 481 (17.15) | 20 (20.41) | 12 (38.71) | |
DM, N (%) | |||||||
Yes | 1784 (27.42) | 18 (85.71) | 172 (36.83) | 1508 (25.99) | 64 (41.02) | 22 (37.93) | < 0.001 |
No | 4572 (70.30) | 3 (14.29) | 292 (62.53) | 4150 (71.53) | 92 (58.98) | 35 (60.34) | |
Borderline | 148 (2.28) | 0 (0) | 3 (0.64) | 144 (2.48) | 0 (0) | 1 (1.73) | |