The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007–2012

Table 3 Association between categorical thyroid status and METS-IR

Model	Variable	Total (n = 6507)				Male (n = 3102)				Female (n = 3405)
Model	Variable	Beta	95% CI		P value	Beta	95% CI		P value	Beta	95% CI		P value
1					< 0.001				< 0.001				< 0.001
	Overt hypothyroidism	0.089	-0.027	0.205	0.132	-0.074	-0.214	0.065	0.296	0.296	0.108	0.486	0.002
	Subclinical hypothyroidism	0.039	0.013	0.065	0.003	0.012	-0.024	0.049	0.503	0.064	0.030	0.100	< 0.001
	Euthyroid	0 (ref)				0 (ref)				0 (ref)
	Subclinical hyperthyroidism	-0.057	-0.100	-0.014	0.009	-0.154	-0.216	-0.092	< 0.001	0.015	-0.044	0.074	0.619
	Overt hyperthyroidism	-0.113	-0.183	0.043	0.002	0.046	-0.114	0.208	0.570	-0.120	-0.202	-0.039	0.004
2					< 0.001				< 0.001				< 0.001
	Overt hypothyroidism	0.009	-0.025	0.024	0.674	0.033	-0.008	0.109	0.078	-0.055	-0.134	0.021	0.247
	Subclinical hypothyroidism	0.012	-0.002	0.032	0.069	0.021	0.002	0.040	0.004	0.001	-0.014	0.017	0.803
	Euthyroid	0 (ref)				0 (ref)				0 (ref)
	Subclinical hyperthyroidism	0.004	-0.014	0.027	0.566	-0.029	-0.059	0.000	0.052	0.028	0.004	0.063	0.035
	Overt hyperthyroidism	0.027	-0.011	0.048	0.201	0.009	-0.041	0.078	0.702	0.017	-0.009	0.046	0.112
3					< 0.001				< 0.001				< 0.001
	Overt hypothyroidism	0.031	0.021	0.044	0.523	-0.049	-0.058	-0.034	0.264	0.174	0.106	0.203	0.426
	Subclinical hypothyroidism	0.019	0.008	0.037	0.057	0.014	0.005	0.022	0.033	0.027	0.018	0.039	0.449
	Euthyroid	0 (ref)				0 (ref)				0 (ref)
	Subclinical hyperthyroidism	-0.034	-0.056	-0.012	0.088	-0.107	-0.129	-0.086	0.069	0.019	0.015	0.026	0.049
	Overt hyperthyroidism	-0.059	-0.081	-0.036	0.104	0.032	0.008	0.067	0.891	0.001	-0.003	0.004	0.097

Model 1 was unadjusted. Model 2 was adjusted for age, sex, race/ethnicity, and the presence of hypertension, hyperlipidemia, and diabetes mellitus. Model 3 was adjusted for age, sex, and race/ethnicity. P-values < 0.05 were considered as statistically significant. CI confidence interval

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