Fig. 2

The RCS model for the dose–response relationship between the SII and a real-world fragile fracture endpoint event in elderly postmenopausal women with T2DM. The adjustment factors included age, hypertension, FT4, 25(OH) D, Hb, ALB, and Cr. After adjusting for confounding factors, a linear regression model was used to fit the data at 4 points in the 5th, 35th, 65th, and 95th percentiles of the SII (the reference value is the 5th percentile). RCS analysis revealed an inverted J-shaped dose-dependent correlation between the SII and a real-world fragile fracture event (P for overall < 0.0001)