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Table 3 Univariate and multivariate Cox regression analyses for evaluating the association between the SII and fragility fractures

From: Systemic immune-inflammatory index predicts fragility fracture risk in postmenopausal anemic females with type 2 diabetes mellitus: evidence from a longitudinal cohort study

SII

HR (95% CI)

Model I

P—values

Model II

P—values

Model III

P—values

All participants

 Low-level SII (≤ 381.32)

Ref

 

Ref

 

Ref

 

 Moderate-level SII (381.32–629.46)

1.967 (1.022–3.785)

0.043*

1.807 (0.938–3.483)

0.077

1.828 (0.942–3.546)

0.074

 High-level SII (≥ 629.46)

3.016 (1.626–5.594)

 < 0.001*

2.625 (1.402–4.917)

0.003*

2.397 (1.222–4.700)

0.011*

 P for trend

 

 < 0.001*

 

0.002*

 

0.009*

  1. Model I: adjusted for none. Model II: adjusted for age and duration of diabetes; Model III: adjusted for age and duration of diabetes, hypertension, Hb, FT4, HDL-C, Cr, 25(OH) D, ALB, and fracture history. P-values indicate statistical differences between the Moderate- or High- and Low-level groups, respectively. P for trend indicates statistical differences between fracture endpoint events and gradient SII levels
  2. Abbreviations: SII systemic immune-inflammatory index, HR hazard ratio, CI confidence interval, Hb hemoglobin, FT4 free thyroxine, HDL-C high-density lipoprotein cholesterol, Cr creatinine, 25(OH) D 25-hydroxyvitamin D, ALB albumin
  3. *P < 0.05