Fig. 1

Cohort inclusion and exclusion strategy and response to GLP-1 M. A. Overview of the cohort building procedure. B. The number of subjects treated with GLP-1 M per year during the defined period (see Methods) in the VUMC Synthetic Derivative database. The years indicated are synthetic time (see Methods). C. Subject responsiveness to GLP-1 M is heterogeneous. Each ‘ + ’ indicates one subject. The blue line indicates an unchanged HbA1C level after GLP-1 M treatment. The blue shading contains subjects whose HbA1C levels were changed by less than ± 0.5% in the treatment period. The green shading contains subjects whose HbA1C decreased by more than 0.5% in the period after treatment. White area contains subjects whose HbA1C increased by 0.5% or more in the time period after treatment