Fig. 3
From: Predicting responsiveness to GLP-1 pathway drugs using real-world data
Distribution of responders and non-responders for several key features. A. Histogram showing range of HbA1C values of the study cohort pre-GLP-1 M treatment. Blue shading: HbA1C values for subjects that did not respond to GLP-1 M treatment. Orange shading: HbA1C values for subjects that responded positively to GLP-1 M treatment. Compared to the non-responder group, the curve for the responder group is right-shifted (toward higher pretreatment HbA1C values). B. Histogram showing BMI values for the study cohort pre-GLP-1 M treatment. Blue shading: BMI values for subjects that did not respond to GLP-1 M treatment. Orange shading: BMI values for subjects that responded positively to GLP-1 M treatment. Compared to the non-responder group, the curve for the responder group has fewer people with BMI lower than 40. C. Mosaic plot showing patient response to GLP-1 M treatment stratified by race. The numbers in the plots indicate the number of the subjects in each group. The top tiles indicate the number of the responders. The bottom tiles indicate the number of non-responders. Tiles from left to right are White, African American and Asian, respectively. D. Mosaic plots showing patient response stratified by NSAIDs usage, sex and age. The numbers in the plots indicate the number of the subjects in each group. Left plot: female subjects; Right plot: male subjects. In both plots, purple tiles indicate subjects treated with both GLP-1 M and NSAIDs, pink tiles indicate subject only treated with GLP-1 M. Top tiles: subjects who started GLP-1 M before or equal to 40 years old. Bottom tiles: subjects who started GLP-1 M after 40. E. Violin plots showing subjects age of the first EHR records of NSAIDs stratified by year and sex. Blue line: median age for Female, Red line, median age for Male