Table 3 Differences in feature values between GLP-1 M responders and non-responders
From: Predicting responsiveness to GLP-1 pathway drugs using real-world data
Features | Number of responders | Responder value mean ± SD | Number of non-responders | Non-responder value mean ± SD | False Discovery Rate (FDR) |
|---|---|---|---|---|---|
HbA1C before treatment | 3447 | 8.87 ± 1.84 | 4409 | 7.34 ± 1.27 | < 1.0E-100 |
HDL cholesterol | 2467 | 42.52 ± 12.19 | 3168 | 44.00 ± 12.92 | 1.04E-05 |
LDL cholesterol | 2282 | 108.66 ± 78.45 | 2997 | 102.79 ± 71.26 | 3.33E-04 |
Triglycerides | 2477 | 222.99 ± 176.99 | 3175 | 199.27 ± 148.61 | 9.54E-08 |
Total cholesterol | 2503 | 179.62 ± 47.28 | 3210 | 173.98 ± 44.62 | 9.08E-06 |
SGOT (AST) | 2838 | 30.56 ± 22.40 | 3642 | 28.21 ± 17.99 | 1.71E-06 |
SGPT (ALT) | 2872 | 35.08 ± 26.65 | 3674 | 31.01 ± 25.16 | 1.81E-18 |
C-peptide | 193 | 4.03 ± 3.25 | 131 | 4.07 ± 3.19 | 4.52E-01 |
Vitamin B12 | 455 | 792.49 ± 998.19 | 639 | 715.79 ± 871.71 | 5.85E-02 |
Blood creatinine | 3169 | 1.03 ± 0.59 | 4022 | 1.10 ± 0.77 | 1.87E-05 |
Fasting blood glucose | 512 | 177.76 ± 69.58 | 703 | 154.94 ± 54.14 | 4.89E-09 |
Random glucose | 2618 | 197.21 ± 80.67 | 3304 | 157.34 ± 58.88 | 5.11E-105 |
Urine glucose | 708 | 64.80 ± 251.71 | 1037 | 7.87 ± 171.95 | 2.52E-09 |
DBP | 3418 | 76.79 ± 9.96 | 4351 | 75.60 ± 9.99 | 1.71E-06 |
SBP | 3418 | 133.42 ± 14.59 | 4351 | 132.48 ± 14.82 | 4.06E-03 |
BMI | 3390 | 35.77 ± 7.95 | 4315 | 35.19 ± 8.16 | 1.14E-04 |
Blood albumin | 2706 | 4.19 ± 0.36 | 3462 | 4.18 ± 0.36 | 3.45E-01 |
Albumin creatinine ratio | 1804 | 75.81 ± 257.71 | 2215 | 70.05 ± 271.26 | 6.24E-08 |
Urine albumin | 1804 | 80.73 ± 263.27 | 2217 | 68.48 ± 251.40 | 7.41E-08 |
Bicarbonate | 157 | 25.10 ± 5.33 | 242 | 25.27 ± 5.28 | 3.44E-01 |
Total blood protein | 1470 | 7.26 ± 0.51 | 2008 | 7.24 ± 0.51 | 6.58E-02 |
Blood calcium | 3123 | 9.54 ± 0.47 | 3964 | 9.51 ± 0.48 | 5.63E-03 |
Blood chloride | 3123 | 101.82 ± 3.37 | 3966 | 102.74 ± 3.29 | 1.21E-29 |
Vitamin D 25OH | 498 | 29.03 ± 13.23 | 717 | 30.56 ± 14.56 | 1.04E-01 |
Whole blood lactate | 94 | 1.51 ± 0.70 | 171 | 1.50 ± 0.81 | 2.91E-01 |
O2 saturation | 101 | 97.39 ± 3.76 | 155 | 97.87 ± 2.58 | 3.45E-01 |
Blood potassium | 3131 | 4.23 ± 0.41 | 3972 | 4.24 ± 0.42 | 1.60E-01 |
Pulse | 2973 | 81.07 ± 12.26 | 3922 | 79.25 ± 11.85 | 1.14E-08 |
Respiration rate | 1640 | 17.49 ± 3.15 | 2198 | 17.47 ± 3.62 | 9.85E-02 |
Blood sodium | 3127 | 138.13 ± 2.64 | 3970 | 138.87 ± 2.50 | 4.29E-33 |
Age | 3447 | 56.61 ± 11.68 | 4409 | 57.83 ± 12.04 | 1.71E-06 |
T2D duration | 3447 | 3.37 ± 3.98 | 4409 | 3.36 ± 3.93 | 3.31E-01 |