Table 4 Advantages of measuring TRAbs

Measurement of TRAbs has a definitive role in various thyroid disorders:

• Differential diagnosis of thyrotoxicosis

• Diagnosis, therapy selection, and prognosis of GD

• Evaluation of thyroid function during pregnancy

• Peri-conceptional and neonatal thyroid workup

• In special situations such as of Graves’ dermopathy (pretibial myxoedema) and Graves’ ophthalmopathy in clinically euthyroid patients, and thyrotoxicosis complicating immune reconstitution syndrome [13, 23]

Based on an evidence-based economic model, the inclusion of TRAbs in GD diagnostic algorithm was found to improve the time to diagnosis by 46%, and reduce the cost of diagnosis by 47% [24], and the definitive diagnosis established by these tests will obviate the need for additional tests [25]