Table 4 Subgroup analysis of BMD at various sites in LT4-treated OH
Sites | Factors | Subgroup | Studies (n) | SMD (95%CI) | I2, % | P value | P value between subgroups |
|---|---|---|---|---|---|---|---|
Lumbar spine | Sex | male | 1 [28] | -0.88 (-1.77, 0.02) | - | 0.050 | 0.030 |
female | -0.26 (-0.55, 0.02) | 56 | 0.070 | ||||
Intervention periods (years) | < 5 | -0.56 (-1.06, -0.06) | 48 | 0.030 | 0.040 | ||
≥ 5 | -0.12 (-0.31, 0.08) | 0 | 0.240 | ||||
Menopausal status | Pre- | 0.01 (-0.43, 0.46) | 55 | 0.950 | 0.310 | ||
Post- | -0.51 (-1.23, 0.21) | 82 | 0.170 | ||||
Femur neck | Sex | male | 1 [28] | -0.51(-1.37, 0.36) | - | 0.250 | 0.110 |
female | -0.25 (-0.63, 0.12) | 75 | 0.180 | ||||
Intervention periods (years) | < 5 | -0.22 (-0.57, 0.14) | 0 | 0.230 | 0.150 | ||
≥ 5 | -0.30 (-0.88; 0.27) | 87 | 0.310 | ||||
Menopausal status | Pre- | -0.33 (-0.92, 0.27) | 75 | 0.280 | 0.130 | ||
Post- | -0.29 (-0.92, 0.33) | 77 | 0.360 | ||||
Trochanter | Sex | male | 1 [28] | -0.33 (-1.19, 0.52) | - | 0.180 | 0.110 |
female | -0.59 (-1.35,0.17) | 93 | 0.130 | ||||
Intervention periods (years) | < 5 | 1 [19] | -0.69 (-1.19, -0.18) | - | 0.007 | 0.120 | |
≥ 5 | -0.56 (-1.52, 0.41) | 95 | 0.260 | ||||
Menopausal status | Pre- | -0.40 (-1.34, 0.53) | 92 | 0.400 | 0.150 | ||
Post- | -0.30 (-0.90, 0.29) | 74 | 0.310 | ||||
Ward’s triangle | Sex | male | 1 [28] | -0.55 (-1.42, 0.31) | - | 0.210 | 0.090 |
female | -0.45 (-1.07, 0.16) | 89 | 0.150 | ||||
Intervention periods (years) | < 5 | 1 [19] | -0.70 (-1.21, -0.20) | - | 0.006 | 0.130 | |
≥ 5 | -0.39 (-1.13, 0.35) | 92 | 0.300 | ||||
Menopausal status | Pre- | -0.22 (-1.03, 0.59) | 86 | 0.590 | 0.260 | ||
Post- | -0.36 (-1.12, 0.39) | 84 | 0.350 |