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Table 1 Association of the concentrations of tryptophan metabolites with metabolic syndrome by binary logistic regression in the elderly

From: Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults

Analytes

MetS vs. Normal

 

Model 1 a

 

Model 2 b

 

Tertile 1 c

Tertile 2 c

Tertile 3 c

Tertile4 c

P for trend

 

Tertile 1 c

Tertile 2 c

Tertile 3 c

Tertile4 c

P for trend

TRP

Ref

1.309 (0.889, 1.928)

1.453 (0.988, 2.136)

2.387 (1.620, 3.517) *

< 0.001

 

Ref

1.602 (1.020, 2.518) *

1.661 (1.058, 2.608) *

2.331 (1.472, 3.692) *

0.001

KYN

Ref

1.058 (0.721, 1.552)

1.190 (0.812, 1.745)

2.047 (1.403, 2.987) *

< 0.001

 

Ref

1.192 (0.770, 1.844)

1.117 (0.721, 1.731)

1.746 (1.132, 2.693) *

0.018

KA

Ref

1.323 (0.898, 1.951)

1.611 (1.094, 2.371) *

2.935 (1.993, 4.324) *

< 0.001

 

Ref

1.249 (0.805, 1.937)

1.384 (0.883, 2.172)

2.291 (1.463, 3.586) *

< 0.001

XA

Ref

1.356 (0.921, 1.997)

1.955 (1.326, 2.882) *

2.414 (1.638, 3.558) *

< 0.001

 

Ref

1.314 (0.844, 2.047)

1.697 (1.095, 2.631) *

1.790 (1.154, 2.774) *

0.005

5-HT

Ref

0.770 (0.531, 1.118)

0.653 (0.449, 0.951) *

0.721 (0.495, 1.049)

0.048

 

Ref

0.843 (0.553, 1.286)

0.864 (0.559, 1.333)

0.944 (0.601, 1.484)

0.721

TA

Ref

1.402 (0.964, 2.040)

1.559 (1.070, 2.271) *

1.089 (0.743, 1.595)

0.197

 

Ref

1.274 (0.831, 1.954)

1.424 (0.928, 2.184)

1.069 (0.695, 1.645)

0.380

IPA

Ref

0.771 (0.530, 1.121)

0.722 (0.495, 1.052)

0.849 (0.585, 1.233)

0.303

 

Ref

0.690 (0.447, 1.065)

0.691 (0.449, 1.063)

0.721 (0.470, 1.107)

0.130

IAA

Ref

0.987 (0.677, 1.440)

1.036 (0.712, 1.506)

1.244 (0.857, 1.805)

0.226

 

Ref

0.961 (0.622, 1.483)

1.129 (0.736, 1.732)

1.259 (0.822, 1.930)

0.212

KYN/TRP

Ref

0.984 (0.674, 1.437)

0.900 (0.614, 1.320)

1.474 (1.009, 2.154) *

0.073

 

Ref

0.900 (0.579, 1.400)

0.800 (0.511, 1.251)

1.409 (0.906, 2.191)

0.169

KA/KYN

Ref

1.070 (0.736, 1.556)

1.056 (0.725, 1.537)

1.201 (0.826, 1.746)

0.354

 

Ref

1.079 (0.701, 1.662)

0.888 (0.576, 1.371)

1.110 (0.713, 1.728)

0.794

XA/TRP

Ref

1.078 (0.741, 1.569)

0.978 (0.672, 1.426)

1.314 (0.899, 1.921)

0.200

 

Ref

1.141 (0.744, 1.749)

1.007 (0.655, 1.549)

1.097 (0.696, 1.729)

0.812

XA/KYN

Ref

0.789 (0.543, 1.147)

0.817 (0.561, 1.188)

0.834 (0.574, 1.212)

0.407

 

Ref

0.667 (0.435, 1.022)

0.665 (0.432, 1.025)

0.711 (0.462, 1.096)

0.164

5-HT/TRP

Ref

0.584 (0.402, 0.849) *

0.498 (0.341, 0.726) *

0.477 (0.327, 0.697) *

< 0.001

 

Ref

0.675 (0.443, 1.028)

0.712 (0.463, 1.093)

0.619 (0.398, 0.962) *

0.038

IPA/TRP

Ref

0.715 (0.491, 1.041)

0.732 (0.502, 1.066) *

0.698 (0.478, 1.017)

0.067

 

Ref

0.644 (0.418, 0.994) *

0.672 (0.436, 1.036)

0.642 (0.415, 0.992) *

0.056

IAA/TRP

Ref

1.025 (0.707, 1.487)

0.703 (0.482, 1.027)

0.844 (0.581, 1.226)

0.182

 

Ref

1.039 (0.681, 1.586)

0.787 (0.510, 1.214)

0.936 (0.607, 1.443)

0.543

  1. Notes
  2. Abbreviations MetS: metabolic syndrome; TRP: tryptophan; KYN: kynurenine; KA: kynurenic acid; IAA: indoleacetic acid; IPA: indolepropionic acid; XA: xanthurenic acid; 5-HT: 5-hydroxytryptamine; TA: tryptamine; Ref: reference
  3. a: Adjusted for age, sex
  4. b: Adjusted for age, sex, region, per capita income, smoking, drinking, consumption of sugar, dietary structure, sedentary time, occupational history, hip circumference, body mass index (BMI), skinfold thickness
  5. c: Binary logistic analysis; Odds ratio (95% confidence interval)
  6. * Statistically significant association (P-value < 0.05)
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BMC Endocrine Disorders

ISSN: 1472-6823

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