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Table 2 Sex-stratified analysis in the association of serum tryptophan metabolites with metabolic syndrome

From: Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults

Analytes

MetS vs. Normal

Males a

 

Females a

Tertile 1 b

Tertile 2 b

Tertile 3 b

Tertile 4 b

 

Tertile 1 b

Tertile 2 b

Tertile 3 b

Tertile 4 b

TRP

Ref

1.384 (0.589, 3.252)

1.563 (0.669, 3.652)

1.800 (0.758, 4.272)

 

Ref

1.651 (0.960, 2.839) *

1.647 (0.955, 2.840) *

2.280 (1.288, 4.035) *

KYN

Ref

1.160 (0.520, 2.586)

1.380 (0.607, 3.138)

1.542 (0.691, 3.442)

 

Ref

1.103 (0.646, 1.882)

0.967 (0.566, 1.652)

1.759 (1.018, 3.038) *

KA

Ref

0.873 (0.377, 2.019)

0.930 (0.408, 2.122)

1.364 (0.608, 3.060)

 

Ref

1.376 (0.813, 2.33)

1.623 (0.939, 2.806)

3.098 (1.761, 5.452) *

XA

Ref

1.987 (0.792, 4.987)

1.940 (0.809, 4.653)

2.126 (0.899, 5.027)

 

Ref

1.119 (0.667, 1.876)

1.716 (1.007, 2.925) *

1.465 (0.853, 2.517)

5-HT

Ref

0.924 (0.445, 1.920)

0.787 (0.360, 1.722)

1.107 (0.511, 2.398)

 

Ref

0.754 (0.441, 1.289)

0.882 (0.513, 1.514)

0.838 (0.468, 1.499)

TA

Ref

1.247 (0.562, 2.769) *

1.247 (0.562, 2.769)

1.247 (0.562, 2.769)

 

Ref

0.975 (0.583, 1.633)

1.453 (0.847, 2.492)

1.017 (0.592, 1.748)

IPA

Ref

0.745 (0.353, 1.571)

0.473 (0.220, 1.016)

0.649 (0.301, 1.399)

 

Ref

0.624 (0.359, 1.087)

0.782 (0.451, 1.354)

0.726 (0.424, 1.242)

IAA

Ref

1.604 (0.706, 3.644)

1.386 (0.599, 3.209)

1.733 (0.766, 3.924)

 

Ref

0.766 (0.449, 1.307)

1.027 (0.610, 1.732)

0.960 (0.567, 1.625)

KYN/TRP

Ref

1.740 (0.771, 3.927)

0.846 (0.364, 1.969)

1.630 (0.741, 3.585)

 

Ref

0.721 (0.419, 1.242)

0.790 (0.453, 1.38)

1.319 (0.748, 2.326)

KA/KYN

Ref

1.108 (0.507, 2.420)

0.705 (0.319, 1.561)

1.144 (0.524, 2.499)

 

Ref

1.102 (0.647, 1.876)

1.115 (0.652, 1.907)

1.228 (0.705, 2.137)

XA/TRP

Ref

1.260 (0.562, 2.825)

1.086 (0.476, 2.478)

1.062 (0.473, 2.382)

 

Ref

1.260 (0.562, 2.825)

1.086 (0.476, 2.478)

1.062 (0.473, 2.382)

XA/KYN

Ref

0.721 (0.334, 1.556)

0.687 (0.317, 1.490)

0.728 (0.329, 1.607)

 

Ref

0.639 (0.375, 1.090)

0.727 (0.420, 1.259)

0.680 (0.397, 1.164)

5-HT/TRP

Ref

1.006 (0.497, 2.037)

0.738 (0.345, 1.578)

0.804 (0.375, 1.726)

 

Ref

0.502 (0.290, 0.869) *

0.706 (0.409, 1.218)

0.520 (0.296, 0.915) *

IPA/TRP

Ref

0.518 (0.248, 1.084)

0.436 (0.204, 0.932) *

0.524 (0.239, 1.148)

 

Ref

0.659 (0.376, 1.155)

0.836 (0.479, 1.459)

0.694 (0.402, 1.198)

IAA/TRP

Ref

0.947 (0.437, 2.050)

0.973 (0.426, 2.224)

1.012 (0.455, 2.251)

 

Ref

1.139 (0.664, 1.953)

0.701 (0.413, 1.189)

0.849 (0.495, 1.456)

  1. Notes
  2. Abbreviations MetS: metabolic syndrome; TRP: tryptophan; KYN: kynurenine; KA: kynurenic acid; IAA: indoleacetic acid; IPA: indolepropionic acid; XA: xanthurenic acid; 5-HT: 5-hydroxytryptamine; TA: tryptamine; Ref: reference
  3. a: Adjusted for age, region, per capita income, smoking, drinking, consumption of sugar, dietary structure, sedentary time, occupational history, hip circumference, body mass index (BMI), skinfold thickness
  4. b: Binary logistic analysis; Odds ratio (95% confidence interval)
  5. * Statistically significant association (P-value < 0.05)
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BMC Endocrine Disorders

ISSN: 1472-6823

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