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Table 2 Parathyroid panel findings in follow-up evaluations after each intervention

From: Comparison of the two treatment methods in primary hyperparathyroidism due to solitary parathyroid adenoma, Ultrasound-guided percutaneous alcohol ablation vs. parathyroidectomy: a randomized controlled trial

Characteristics

Group

Follow up

P*

24 h

2 weeks

3 months

6 months

Serum-adjusted Ca (mg/dL)

Reference range [8.6–10.2 mg/dL]

PEA

Overall (n = 68)

9.3 ± 0.4

9.4 ± 0.4

9.0 ± 0.2

8.8 ± 0.3

< 0.001

Complete response (n = 62)

9.3 ± 0.4

9.3 ± 0.4

9.0 ± 0.2

8.8 ± 0.2

< 0.001

Partial response (n = 4)

9.1 ± 0.26

9.4 ± 0.13

9.1 ± 0.1

8.8 ± 0.1

< 0.001

Disease persistence (n = 2)

10.0 ± 0.07

9.8 ± 0.07

9.7 ± 0.07

10.3 ± 0.07

-

P†

0.04

0.36

0.002

< 0.001

-

PTx (n = 68)

9.2 ± 0.4

9.4 ± 0.5

8.9 ± 0.3

8.7 ± 0.4

< 0.001

P‡

0.23

0.56

0.08

0.25

-

PTH (pg/mL)

Reference range [10–65 pg/mL]

PEA

Overall (n = 68)

54.2 ± 14.2

44.0 ± 13.9

38.2 ± 13.9

31.3 ± 15.8

< 0.001

Complete response (n = 62)

52.0 ± 7.3

42.4 ± 9.7

35.0 ± 8.9

27.1 ± 8.4

< 0.001

Partial response (n = 4)

55.7 ± 5.0

40.5 ± 1.0

61.2 ± 1.8

73.5 ± 7.1

< 0.001

Disease persistence (n = 2)

121.5 ± 30.4

101.5 ± 23.3

89.5 ± 13.4

77.0 ± 2.82

0.08

P†

< 0.001

< 0.001

< 0.001

< 0.001

-

PTx (n = 68)

53.6 ± 9.7

45.7 ± 12.1

38.3 ± 12.0

29.9 ± 12.6

< 0.001

P‡

0.75

0.45

0.95

0.565

-

Phosphorus

Reference range [3.0–4.5 mg/dL]

PEA

Overall (n = 68)

3.3 ± 0.4

3.4 ± 0.4

3.3 ± 0.2

3.5 ± 0.3

< 0.001

Complete response (n = 62)

3.3 ± 0.4

3.4 ± 0.3

3.3 ± 0.2

3.5 ± 0.3

< 0.001

Partial response (n = 4)

3.2 ± 0.5

3.7 ± 0.6

3.3 ± 0.2

3.5 ± 0.3

< 0.001

Disease persistence (n = 2)

3.0 ± 0.0

3.1 ± 0.07

3.0 ± 0.07

3.0 ± 0.0

-

P†

0.50

0.2

0.36

0.12

-

PTx (n = 68)

3.3 ± 0.4

3.4 ± 0.3

3.4 ± 0.5

3.8 ± 0.4

< 0.001

P‡

0.79

0.93

0.06

< 0.001

-

Alkaline phosphatase (U/L)

Reference range [30–120 U/L]

PEA

Overall (n = 68)

222.1 ± 101.8

183.4 ± 103.7

157.9 ± 30.1

143.3 ± 33.0

< 0.001

Complete response (n = 62)

224.8 ± 104.4

183.2 ± 107.0

156.3 ± 23.8

139.6 ± 20.4

< 0.001

Partial response (n = 4)

166.2 ± 72.0

158.2 ± 67.6

135.7 ± 43.0

129.0 ± 38.9

0.012

Disease persistence (n = 2)

249.5 ± 9.1

239.5 ± 2.1

254.0 ± 5.6

287.0 ± 8.4

0.006

P†

0.50

0.67

< 0.001

< 0.001

-

PTx (n = 68)

284.7 ± 105.1

272.0 ± 100.1

161.5 ± 12.9

145.9 ± 17.3

< 0.001

P‡

0.001

< 0.001

0.37

0.57

-

  1. PEA: percutaneous ethanol ablation, PTH: parathyroid hormone, PTx: parathyroidectomy
  2. * Repeated measure for postoperative assessments in one group between different timing
  3. † ANOVA was used for these p-values
  4. ‡ Independent t-test was used for these p-values
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BMC Endocrine Disorders

ISSN: 1472-6823

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