Assessment of the impact of HIV infection on the hypothalamic-pituitary-ovarian axis and pubertal development among adolescent girls at a tertiary centre in Zimbabwe: a cross-sectional study

Table 2 Pubertal milestones among HIV-infected girls against Tanner staging ( pubic hair and breast ) and menarche. **p < 0.05

Tanner stage		Delayed pubertal milestone	Age at pubertal milestone mean (2*SD range)
	N	n(%)	Reference group	Study group
Breast*
Tanner 2	15	3(20.0)	11.2(9.0-13.4)	13.1 (9.6–16.7)**
Tanner 3	13	2(15.4)	12.2(10.0-14.3)	13.6(11.0-16.3)**
Tanner 4	38	16(43.2)	13.1(10.8–15.4)	15.4(11.1–19.8)**
Tanner 5	33	7(21.0)	15.3(11.9–18.8)	17.0(13.3–20.7)**
Total	101	28(28.6)	11.2(9.0-13.4)	13.1 (9.6–16.7)**
p-value		0.113
Pubic hair
Tanner 2	16	1(6.3)	11.7(9.3–14.1)	12.9(10.6–15.3)**
Tanner 3	15	5(33.3)	12.4(10.2–14.6)	14.3(10.2–18.4)**
Tanner 4	40	21(52.5)	13.0 (10.8–15.1)	15.8(11.5–20.1)**
Tanner 5	23	17(73.9)	14.4 (12.2–16.7)	17.0(13.6–20.5)**
Total	101	44(46.8)	11.7(9.3–14.1)	12.9(10.6–15.3)**
p-value		< 0.001
Menarche
Yes	72	9(12.5)	13.5(11.4–15.5)	16.3(12.3–20.3)**
No	29	1(3.4)

* 3 and 7 participants had missing data concerning the Tanner stages for breast and pubic hair, respectively

ISSN: 1472-6823