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Table 1 Study characteristics of the published studies included in the meta-analysis

From: Relationship of asprosin and diabetes: a meta-analysis

Author

Publication Year

Study Period

Ethnicity

Region

Number (n)

Level of Asprosin

Details

Sample

Case

Control

Case

Control

Case

Control

Wang Y

2018

Asian

China

51

52

73.25 ± 91.69 ng/mL

16.22 ± 9.27 ng/mL

M 27, F 24; 53.73 ± 10.06 years; T2DM

M 17, F 35; 54.73 ± 11.90 years

Plasma

Zhang L

2019

March to June 2017

Asian

China

84

86

3.52 ± 4.2 ng/mL

1.77 ± 1.64 ng/mL

M 52, F 32; 49.93 ± 10.99 years; newly diagnosed T2DM

M 49, F 37; 47.60 ± 7.95 years

Serum

Zhang H

2020

April to December 2019

Asian

China

42

30

6.23 ± 0.87 ng/mL

5.08 ± 1.31 ng/mL

M 23, F 19; 55.98 ± 8.59 years; T2DM; duration of DM: 10.0 (6.0–13.0) years

M 14, F 16; 54.30 ± 4.92 years

Serum

Zhong L

2020

Asian

China

40

40

1.35 ± 0.68 ng/mL

0.5 ± 0.84 ng/mL

All females; 34.18 ± 3.24 years; GDM; gestational age: 270.45 ± 8.81 days

All females; 34.2 ± 3.31 years; gestational age: 273.63 ± 6.51 days

Plasma

Zhang X

2020

May to December 2018

Asian

China

60

60

6.2 ± 1.13 ng/mL

5.22 ± 1.26 ng/mL

M 32, F 28; 56.40 ± 7.49 years; T2DM

M 34, F 26; 54.62 ± 5.97 years

Serum

Naiemian S

2020

August to December 2018

Asian

Iran

97

97

4.18 ± 3.26 ng/mL

3.5 ± 1.37 ng/mL

M 50, F 47; 54 ± 7 years; newly diagnosed T2DM

M 50, F 47; 52 ± 10 years

Serum

Goodarzi G

2021

January 2019 to Jan 2020

Asian

Iran

54

55

6.7 ± 1.35 nmol/L

4.81 ± 1.09 nmol/L

M 32, F 22; 61.83 ± 7.78 years; T2DM

M 36, F 19; 58.71 ± 7.93 years

Serum

Gozel N

2021

Caucasian

Turkey

30

30

49.52 ± 41.98 ng/mL

25.16 ± 14.49 ng/mL

M 17, F 13; 54.63 ± 10.8 years; newly diagnosed T2DM; treated with metformin

M 16, F 14; 30.10 ± 8.8 years

Plasma

You M

2022

June to October 2021

Asian

China

33

30

173 ± 40.7 ng/mL

158.5 ± 10.25 ng/mL

M 18, F 15; 60.85 ± 13.91 years; T2DM; duration of DM: 8 (3–14) years

M 16, F 14; 60.63 ± 8.08 years

Serum

Dai C

2022

February 2021 to January 2022

Asian

China

90

66

7.38 ± 1.08 ng/mL

5.87 ± 0.71 ng/mL

M 48, F 42; 54.91 ± 8.24 years; T2DM, treated with liraglutide

M 35, F 31; 52.15 ± 7.97 years

Serum

Atli H

2022

May to August 2021

Caucasian

Turkey

21

21

28.22 ± 15.41 ng/mL

25.49 ± 12.37 ng/mL

M 9, F 12; 56.05 ± 10.54 years; T2DM

M 15, F 6; 42.70 ± 7.55 years

Serum

Timurkaan M

2022

Caucasian

Turkey

60

60

47.7 ± 26.5 ng/mL

35.7 ± 12.7 ng/mL

M 30, F 30; 50.3 ± 5.76 years; newly diagnosed T2DM

M 29, F 31; 47.6 ± 7.64 years

Plasma

Boz IB

2023

October 2019 to November 2020

Caucasian

Turkey

30

33

42.8 ± 7.63 ng/mL

20.5 ± 8.0 ng/mL

All females; 33.6 ± 5.6 years; GDM; gestational age: 27.1 ± 3.1 weeks

All females; 27.6 ± 4.6 years; gestational age: 25.6 ± 6.2 weeks

Serum

Nedeva IS

2023

February 2020 to August 2021

Caucasian

Bulgaria

38

42

1.09 ± 0.51 ng/mL

0.71 ± 0.28 ng/mL

54.32 ± 10.97 years; newly diagnosed DM

47.71 ± 12.91 years

Serum

  1. T2DM: Type 2 diabetes mellitus; DM: diabetes mellitus; GDM: gestational diabetes mellitus