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Table 5 Diagnostic performance of different factors for identifying Hypercholesteremia and obesity

From: Exploring serum miR-33b as a novel diagnostic marker for hypercholesterolemia and obesity: insights from a pilot case-control study

Ā 

Hypercholesterolemia

Obesity

AUC (95% CI)

Cut point

Sensitivity

Specificity

PPV

P values

AUC (95% CI)

Cut point

Sensitivity

Specificity

PPV

P values

BMI

0.19 (0.06, 0.32)

0.00

0.00

1.00

0.65

0.0001

1.00 (1.00, 1.00)

24.96

1.00

1.00

1.00

0.0001

HDL-c

0.81 (0.64, 0.97)

56

0.60

1.00

0.00

0.0003

0.26 (0.11, 0.41)

73

0.00

1.00

Ā 

0.0017

LDL-c

1.00 (1.00, 1.00)

137

1.00

1.00

1.00

0.0001

0.25 (0.11, 0.39)

56.20

1.00

0.07

1.00

0.0005

miR-33b

0.74 (0.60, 0.88)

3.07

1.00

0.53

1.00

0.0012

0.76 (0.62, 0.90)

3.45

0.80

0.73

0.87

0.0003

TC

1.00 (1.00, 1.00)

197

1.00

1.00

1.00

0.0001

0.31 (0.16, 0.46)

Ā Ā Ā Ā 

0.0145

THR

0.67 (0.50, 0.84)

Ā Ā Ā Ā 

0.051

0.54 (0.37, 0.71)

4

0.87

0.37

0.83

0.639

TG

0.75 (0.60, 0.90)

113

0.80

0.73

0.40

0.001

0.64 (0.46, 0.81)

90

0.73

0.53

0.56

0.122

TyG

0.78 (0.64, 0.93)

Ā Ā Ā Ā 

0.0001

0.62 (0.45, 0.79)

8.28

0.87

0.47

0.57

0.153

  1. AUC, area under curve; BMI, body mass index; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; PPV, Positive Predictive Value; TC, total cholesterol; TG, triglyceride; TyG, triglyceride-glucose index; THR, TC/HDL-c ratio