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Table 3 Association between liver enzymes and prediabetes stratified by gender

From: The relationship between hepatic enzymes, prediabetes, and diabetes in the Azar cohort population

Pre-Diabetes

 

Crude model OR (95%CI)

Adjusted model 1 OR (95%CI)

Adjusted model 2 OR (95%CI)

AST

 

 Quartile 1

Reference

 Quartile 2

1.12(0.99–1.27)

1.05 (0.93–1.22)

1.02(0.89–1.16)

 Quartile 3

1.18(1.04–1.33)

1.10(0.97–1.25)

1.06(0.93–1.20)

 Quartile 4

1.27(1.12–1.44)

1.26(1.11–1.43)

1.18(1.04–1.35)

ALT

   

 Quartile 1

Reference

  

 Quartile 2

1.17(1.02–1.33)

1.09(0.95–1.25)

1.05(0.91–1.20)

 Quartile 3

1.42(1.25–1.61)

1.39(1.22–1.59)

1.29(1.13–1.47)

 Quartile 4

1.65(1.45–1.88)

1.83(1.60–2.09)

1.61(1.40–1.85)

GGT

   

 Quartile 1

Reference

  

 Quartile 2

1.29(1.13–1.46)

1.27(1.11–1.45)

1.22(1.07–1.39)

 Quartile 3

1.79(1.57–2.04)

1.82(1.59–2.09)

1.69(1.47–1.94)

 Quartile 4

1.95(1.71–2.22)

2.01(1.76–2.31)

1.85(1.61–2.13)

ALP

   

 Quartile 1

Reference

  

 Quartile 2

1.30(1.14–1.49)

1.22(1.06–1.39)

1.20(1.05–1.38)

 Quartile 3

1.48(1.29–1.68)

1.31(1.15–1.50)

1.28(1.12–1.46)

 Quartile 4

1.94(1.71–2.21)

1.65(1.45–1.89)

1.60(1.40–1.83)

Gender

   

Male

   

AST

   

 Quartile 1

Reference

  

 Quartile 2

1.03(0.83–1.27)

1.05(0.84–1.30)

0.96(0.77–1.20)

 Quartile 3

1.09(0.90–1.33)

1.14(0.93–1.39)

1.01(0.82–1.24)

 Quartile 4

1.18(0.97–1.44)

1.29(1.06–1.57)

1.12(0.91–1.37)

ALT

   

 Quartile 1

Reference

  

 Quartile 2

0.92(0.72–1.18 )

0.94(0.73–1.19)

0.88(0.68–1.12)

 Quartile 3

1.29(1.03–1.61)

1.40(1.11–1.76)

1.19(0.94–1.51)

 Quartile 4

1.53(1.23–1.89)

1.86(1.49–2.32)

1.49(1.18–1.88)

GGT

   

 Quartile 1

Reference

  

 Quartile 2

1.34(1.04–1.73)

1.35(1.05–1.74)

1.28(0.99–1.66)

 Quartile 3

1.84(1.44–2.34)

1.88(1.48–2.40)

1.72(1.34–2.21)

 Quartile 4

2.0(1.58–2.53)

2.09(1.64–2.65)

1.84(1.43–2.36)

ALP

   

 Quartile 1

Reference

  

 Quartile 2

1.14(0.94–1.39)

1.13(0.93–1.38)

1.15(0.94–1.41)

 Quartile 3

1.23(1.01–1.49)

1.22(1.00-1.49)

1.24(1.02–1.51)

 Quartile 4

1.43(1.17–1.74)

1.41(1.16–1.73)

1.44(1.17–1.76)

Female

   

AST

   

 Quartile 1

Reference

  

 Quartile 2

1.18(1.01–1.39)

1.05(0.89–1.23)

1.03(0.88–1.22)

 Quartile 3

1.25(1.06–1.47)

1.05(0.89–1.24)

1.05(0.89–1.24)

 Quartile 4

1.39(1.16–1.66)

1.17(0.98–1.41)

1.17(0.97–1.41)

ALT

   

 Quartile 1

Reference

  

 Quartile 2

1.33(1.13–1.55)

1.17(1.0-1.37)

1.14(0.97–1.34)

 Quartile 3

1.54(1.31–1.82)

1.35(1.14–1.59)

1.30(1.09–1.54)

 Quartile 4

1.86(1.54–2.24)

1.65(1.37-2.00)

1.54(1.27–1.87)

GGT

   

 Quartile 1

Reference

  

 Quartile 2

1.32(1.13–1.54)

1.22(1.04–1.43)

1.18(1.01–1.39)

 Quartile 3

1.98(1.66–2.34)

1.79(1.51–2.13)

1.66(1.39–1.98)

 Quartile 4

2.27(1.90–2.71)

1.95(1.62–2.34)

1.84(1.53–2.21)

ALP

   

 Quartile 1

Reference

  

 Quartile 2

1.42(1.19–1.70)

1.26(1.05–1.51)

1.23(1.02–1.48)

 Quartile 3

1.69(1.42–2.03)

1.35(1.12–1.62)

1.28(1.07–1.55)

 Quartile 4

2.43(2.05–2.89)

1.80(1.50–2.15)

1.70(1.42–2.04)

  1. Model1: adjusted for age and gender (if appropriate); Model2: adjusted for age, gender, BMI, WSI, physical activity level, smoking status