Table 4 The association between genetic variations (SNPs) in the CDKAL1 gene and the risk of developing GDM in the age 30 or older

rs7754840 G > C

Codominant Model

GG

85 (42.93)

111(36.04)

1(ref)

1(ref)

CG

88 (44.44)

148(48.05)

1.288 (0.875–1.896)

0.200

1.282 (0.862–1.907)

0.220

CC

25(12.63)

49(15.91)

1.501 (0.859–2.623)

0.154

1.538 (0.868–2.727)

0.140

Allele Model

G

258(65.1)

370(60)

1(ref)

1(ref)

C

138(34.8)

246(39.9)

1.243 (0.956–1.616)

0.104

0.795 (0.608–1.039)

0.093

Dominant Model

GG

85 (42.93)

111(36.04)

1(ref)

1(ref)

CC + GC

113 (57.07)

197 (63.96)

1.335 (0.927–1.923)

0.121

1.342 (0.922–1.952)

0.125

Recessive Model

GC + GG

173 (87.37)

259 (84.09)

1(ref)

1(ref)

CC

25(12.63)

49(15.91)

1.309 (0.779–2.199)

0.309

1.360 (0.801–2.309)

0.254

Over dominant Model

CC + GG

110 (55.56)

160 (51.95)

1(ref)

1(ref)

GC

88(44.44)

148(48.05)

0.865 (0.604–1.238)

0.427

1.38 (0.787–1.643)

0.493

rs7756992 A > G

Codominant Model

AA

65(32.83)

90(29.22)

1(ref)

1(ref)

AG

88(44.44)

148(48.05)

1.215 (0.803–1.838)

0.357

1.179 (0.773–1.799)

0.445

GG

45(22.73)

70(22.73)

1.123 (0.687–1.837)

0.643

1.165 (0.698–1.943)

0.559

Allele Model

A

218(0.55)

328(0.532)

1(ref)

1(ref)

G

178(0.449)

288(0.467)

1.075 (0.835–1.386)

0.574

1.076 (0.830–1.394)

0.580

Dominant Model

AA

65(32.83)

90(29.22)

1(ref)

1(ref)

GG + AG

133 (67.17)

218 (70.78)

1.184 (0.805–1.740)

0.390

1.161 (0.783–1.721)

0.457

Recessive Model

AG + AA

153 (77.27)

238 (77.27)

ref

Ref

GG

45(22.73)

70(22.73)

1.000 (0.653–1.531)

1.000

1.025 (0.663–1.585)

0.912

Overdominant Model

GG + AA

110 (55.56)

160 (51.95)

1(ref)

1(ref)

AG

88(44.44)

148(48.05)

1.156 (0.808–1.655)

0.427

1.118 (0.775–1.614)

0.551