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Table 5 Risk factors for time to Locoregional recurrence

From: Insular thyroid carcinoma: epidemiological pattern, factors contributing to recurrence and distant metastasis

Risk factor

n/N (%)

Median survival (95% CI)

RMST at 24-months

Log rank test

HR (95% CI)

Mean (95% CI)

p-value

χ2

p-value

Age (years)

   

0.369

0.568

0.451

 

 ≥ 60

3/10 (30)

24 (7–84)

19.8 (12.5–27)

   

r (1)

 < 60

7/14 (50)

18 (9–72)

15.7 (10.8–20.7)

   

1.7 (0.42–7.1)

Sex

   

0.025

4.097

0.043

 

 Female

5/15 (33.3)

72 (9–84)

20.6 (16.5–24.7)

   

r (1)

 Male

5/9 (55.6)

9 (1–18)

11.9 (5.5–18.4)

   

5 (1.05–23.4)

Comorbidity

   

0.690

0.062

0.804

 

 No

4/11 (36.4)

24 (2–24)

17.8 (12.2–23.4)

   

r (1)

 Yes

6/13 (46.2)

18 (7–84)

16.2 (10.2–22.1)

   

1.2 (0.29–4.9)

Focality

   

0.075

2.379

0.123

 

 Unifocal

4/13 (30.8)

72 (-)

19.9 (15.8–23.9)

   

r (1) 

 Multifocal

6/11 (54.6)

12 (1–84)

12.2 (4.8–19.6)

   

3.1 (0.74–12.9) 

Adjuvant RAIa

   

0.205

8.255

0.004

 

 Yes

7/15 (46.7)

72 (9–84)

8.5 (7.4–9.5)

   

r (1)

 No

3/9 (33.3)

7 (1–9)

6.6 (3.9–9.3)

   

39.7 (3.2–490)

  1. n/N Frequency of events / number of cases, RMST Restricted mean survival time, HR Hazard ratio, c2: Chi-square, r (1): Reference category
  2. aRMST was readjusted at time point 9 months