Table 7 Risk factors for time to distant metastasis
Risk factor | n/N (%) | Median survival (95% CI) | RMST at 24-months | Log rank test | HR (95% CI) | ||
|---|---|---|---|---|---|---|---|
Mean (95% CI) | p-value | χ2 | p-value | ||||
Age (years) | Â | Â | Â | 0.788 | 0.644 | 0.422 | Â |
 < 60 | 6/14 (42.9) | 72 (3–72) | 16.9 (11.8–22.1) |  |  |  | r (1) |
 ≥ 60 | 4/10 (40) | 24 (0–60) | 18.2 (10.9–25.4) |  |  |  | 1.8 (0.43–7.6) |
Sex | Â | Â | Â | 0.181 | 1.392 | 0.238 | Â |
 Female | 6/15 (40) | 60 (12–72) | 19.3 (14.6–24) |  |  |  | r (1) |
 Male | 4/9 (44.4) | 18 (0–18) | 13.4 (6.1–20.7) |  |  |  | 2.5 (0.54–12) |
Comorbidity | Â | Â | Â | 0.440 | 0.617 | 0.432 | Â |
 No | 5/11 (45.5) | 24 (0–24) | 15.5 (8.9–22) |  |  |  | r (1) |
 Yes | 5/13 (38.5) | 60 (1–72) | 18.8 (13.6–24) |  |  |  | 0.57 (0.14–2.3) |
Focality | Â | Â | Â | 0.779 | 0.136 | 0.712 | Â |
 Unifocal | 6/13 (46.2) | 72 (0–72) | 15.8 (9.8–21.8) |  |  |  | r (1) |
 Multifocal | 4/11 (36.4) | 24 (3–60) | 17.2 (9.8–24.5) |  |  |  | 1.3 (0.33–5.2) |
Adjuvant RAI | Â | Â | Â | 0.145 | 1.888 | 0.169 | Â |
 Yes | 9/15 (60) | 24 (1–72) | 16 (10.7–21.2) |  |  |  | r (1) |
 No | 1/9 (11.1) | - (-) | 21.3 (16.4–26.3) |  |  |  | 0.36 (0.08–1.5) |