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Table 3 Multivariate Cox regression analyses for evaluating the association between SAR and fragility fractures

From: Systemic immune-inflammation index to albumin (SII/ALB) ratio as a novel dual-dimensional powerful predictor for hip fractures in elderly females with diabetes: a postmenopausal longitudinal cohort study

SAR

Case/total

HR (95% CI)

Model I

P - values

Model II

P - values

Model III

P - values

All participants

69/363

1.004 (1.003–1.004)

< 0.001*

1.003 (1.002–1.004)

< 0.001*

1.003 (1.002–1.005)

< 0.001*

Low-level (≤ 98.24)

11/121

Ref

 

Ref

 

Ref

 

Moderate-level (98.24–157.25)

16/121

1.518 (0.704–3.270)

0.287

1.516 (0.703–3.267)

0.288

1.299 (0.587–2.875)

0.518

High-level (≥ 157.25)

42/121

4.526 (2.329–8.795)

< 0.001*

3.696 (1.892–7.220)

< 0.001*

2.823 (1.370–5.814)

0.005*

P for trend

  

< 0.001*

 

< 0.001*

 

0.005*

  1. Notes: Model I: adjusted for none. Model II: adjusted for age and duration of diabetes; Model III: adjusted for age and duration of diabetes, hypertension, DPN, PVD, BMI, FBG, HbA1c, Hb, TSH, FT3, FT4, TC, TG, HDL-C, LDL-C, Cr, UA, Ca, 25(OH) D, osteoporosis, fracture history. * P < 0.05
  2. Abbreviations: SAR, systemic immune-inflammatory index to ALB (SII/ALB) ratio; SII, systemic immune-inflammatory index; ALB, albumin; HR, hazard ratio; CI, confidence interval; DPN, diabetic peripheral neuropathy; PVD, peripheral vascular disease; BMI, body mass index; FBG, fasting blood glucose; HbA1c, glycated hemoglobin; Hb, hemoglobin; TSH, thyrotropin; FT3, free triiodothyronine; FT4, free thyroxine; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Cr, creatinine; UA, uric acid; Ca, calcium; 25(OH) D, 25-hydroxyvitamin D
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BMC Endocrine Disorders

ISSN: 1472-6823

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