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Table 3 The associations of eGDR with the risk of MASLD and liver fibrosis (NHANES 2017–2018)

From: The association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease and liver fibrosis in US adults

eGDR, mg/kg/min

Case/totals

Crude Model

OR (95%CI)

P

Model I

OR (95%CI)

P

Model II

OR (95%CI)

P

MASLD

       

Per 1 SD increase

1928/3100

0. 37 (0.33–0.41)

< 0.01

0.47 (0.48–0.71)

< 0.01

0.53 (0.48–0.74)

< 0.01

Quartiles

       

eGDR < 4.87

686/773

Ref.

1.0

Ref.

1.0

Ref.

1.0

eGDR 4.87–6.49

519/777

0.26 (0.19–0.33)

< 0.01

0.54 (0.32–0.87)

< 0.01

0.54 (0.32–0.89)

0.02

eGDR 6.49–9.31

458/775

0.18 (0.14–0.24)

< 0.01

0.48 (0.28–0.81)

< 0.01

0.51 (0.30–0.86)

0.01

eGDR ≥ 9.31

265/775

0.07 (0.05–0.09)

< 0.01

0.24 (0.13–0.42)

< 0.01

0.25 (0.14–0.45)

< 0.01

P for trend

 

< 0.01

 

< 0.01

 

< 0.01

 

liver fibrosis

       

Per 1 SD increase

265/3100

0. 35 (0.31–0.41)

< 0.01

0.37 (0.26–0.51)

< 0.01

0.40 (0.28–0.57)

< 0.01

Quartiles

       

eGDR < 4.87

210/773

Ref.

1.0

Ref.

1.0

Ref.

1.0

eGDR 4.87–6.49

68/777

0.26 (0.19–0.44)

< 0.01

0.36 (0.20–0.61)

< 0.01

0.41 (0.23–0.72)

0.02

eGDR 6.49–9.31

66/775

0.25 (0.18–0.33)

< 0.01

0.24 (0.12–0.46)

< 0.01

0.28 (0.14–0.54)

0.01

eGDR ≥ 9.31

17/775

0.06 (0.03–0.10)

< 0.01

0.10 (0.03–0.27)

< 0.01

0.12 (0.04–0.32)

< 0.01

P for trend

 

< 0.01

 

< 0.01

 

< 0.01

 
  1. Note: Crude Model: unadjusted any factor
  2. Model I was adjusted for age, gender, race, marital, education, PIR, fasting glucose, ALT, AST, eGFR, HLD-C and UA. Model II was adjusted for Model I, diabetes mellitus, dyslipidemia, moderate PA, smoking status
  3. Abbreviations: 95% CI: 95% confidence interval; OR: odds ratio; PIR: the ratio of family income to poverty; ALT: Alanine aminotransferase, AST: Aspartate aminotransferase, eGFR: Estimated glomerular filtration rate, HLD-C: High-density lipoprotein cholesterol, UA: uric acid; PA: Physical activity; MASLD: metabolic dysfunction-associated steatotic liver disease