Fig. 2

A. Forest plot diagram showing the association between the SNV of NOS1AP (rs1963645) and DPN. B. Forest plot diagram of heterogeneous studies of SNVs associated with DPN, revealing an association between the THEG5 gene and DPN. Conversely, polymorphisms in XIRP2, IMPA2, LOC101927394, and WBSCR17 appear to act as protective factors against the development of DPN. C. Forest plot diagram for studies on SNVs associated with DPN. Protective SNVs include HDAC4, GUF1, CSMD1, OPCML, ESRRB, and MX1 genes. The SNV associated with DPN is KIAA1279. Heterogeneity Test Statistic (Q); Degrees of Freedom (df); Heterogeneity (I²)