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Table 1 Assessment of the quality of case-control and cross-sectional studies using the Newcastle-Ottawa scale

From: Polymorphic variants and risk of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: systematic review and meta-analysis

Case-control studies

Authors and years

Selection

Comparability

Exposition

Score

Judgement

Is the case definition appropriate? (1)

Representativeness of the cases (2)

Selection of controls (3)

Definition of controls(4)

The study controls for the most important factor (5)

The study controls for any additional important factor(s) (6)

Determination of exposure (7)

Same method of determining cases and controls (8)

Non-response rate* (9)

Meng et al. 2015 [22]

--

NA

7

Good quality

Meng et al. 2015 [23]

--

NA

7

Good quality

Chehadeh et al. 2021 [24]

--

NA

7

Good quality

Ustinova et al. 2021 [25]

--

NA

7

Good quality

Cross-sectional studies

 

Representativeness of the sample (10)

Size of the sample (11)

Not surveyed (12)

Determination of exposure (risk factor) (13)

The study controls for the most important factor (14)

The study controls for any additional factor (15)

Outcome assessment (16)

Statistical analysis (17)

  

Margolis et al. 2013 [19]

--

--

--

--

6

Acceptable quality

Tang et al. 2019 [20]

10

Very good quality

Mansour et al. 2023 [26]

9

Very good quality

  1. 1. Is the case definition appropriate? A star was assigned to studies that had some form of independent validation
  2. 2. Representativeness of the cases: A star was assigned to studies with a representative case series
  3. 3. Selection of controls: A star was assigned if their control series was community-based
  4. 4. Definition of controls: A star was assigned if controls did not have a history of DPN
  5. 5. The study controls for the most important factor: A star was assigned if adjustment has been made, methodological or statistical, for the most important covariate
  6. 6. The study controls for any additional important factor(s): A star was assigned if adjustment has been made, methodological or statistical, for other covariates
  7. 7. Determination of exposure: A star was assigned if the study mentions that they had a safe registry and/or a structured interview where the participant is unaware of their case/control status
  8. 8. Same method of determining cases and controls: A star was assigned if the study mentions the same method
  9. 9. Non-response rate (*): In the studies considered for this systematic review, surveys were not used, so “none of the above” (NA) was selected
  10. 10. Representativeness of the sample: A star was assigned to studies that had adequate representation of the target population
  11. 11. Size of the sample: A star was assigned to studies with a justified and satisfactory sample size
  12. 12. Not surveyed: A star was assigned if comparability was established between the characteristics of surveyed and not surveyed, and the response rate was satisfactory
  13. 13. Determination of exposure: Two stars were assigned if the dependent variable has been measured with a validated instrument, and one star if it is not a validated instrument but is available or described
  14. 14. The study controls for the most important factor: An adjustment has been made, methodological or statistical, for the most important covariate
  15. 15. The study controls for any additional factor: An adjustment has been made, methodological or statistical, for other covariates.
  16. 16. Outcome assessment: Two stars were assigned if the study mentions an independent blind assessment or if its records are linked, and one star if it was self-reported
  17. 17. Statistical analysis: A star was awarded if the study mentions whether subjects from different outcome groups are comparable, according to the study’s design or analysis, and confounding factors are controlled